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  1. Content type: Case report

    Heparin-induced thrombocytopenia (HIT) is a life and limb-threatening condition caused by the binding of platelet-activating antibodies (IgG) to multimolecular platelet factor 4 (PF4)/heparin complexes because...

    Authors: Daniel E. Ezekwudo, Rebecca Chacko, Bolanle Gbadamosi, Syeda Batool, Sussana Gaikazian, Theodore E. Warkentin, Jo-Ann I. Sheppard and Ishmael Jaiyesimi

    Citation: Experimental Hematology & Oncology 2017 6:21

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  2. Content type: Review

    B cell lymphoma and multiple myeloma (MM) are the most common hematological malignancies which benefit from therapeutic monoclonal antibodies (mAbs)-based immunotherapies. Despite significant improvement on pa...

    Authors: Li Zhang, Yu-Tzu Tai, Matthew Zhi Guang Ho, Lugui Qiu and Kenneth C. Anderson

    Citation: Experimental Hematology & Oncology 2017 6:20

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  3. Content type: Research

    Inflammation is a major feature of sickle cell disease (SCD). Low-dose methotrexate (MTX) has long been used in chronic inflammatory diseases. This pilot study examined the MTX effect on acute vaso-occlusive p...

    Authors: Silvia R. Brandalise, Rosemary Assis, Angelo B. A. Laranjeira, José Andrés Yunes and Pedro O. de Campos-Lima

    Citation: Experimental Hematology & Oncology 2017 6:18

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  4. Content type: Review

    Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in ...

    Authors: Ying Li and Xin Wang

    Citation: Experimental Hematology & Oncology 2017 6:17

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  5. Content type: Research

    Multiple myeloma (MM) is a type of hematological malignancy with significant heterogeneity in clinical features and prognosis. Cytogenetic abnormalities are the major factors affecting patient outcomes. Studie...

    Authors: GuoQing Wei, LiJun Wang, HanJin Yang, XiaoYan Han, GaoFeng Zheng, WeiYan Zheng, Jie Sun, JiMin Shi, WenJun Wu, Yi Zhao, DongHua He, Bo Wang, Zhen Cai and JingSong He

    Citation: Experimental Hematology & Oncology 2017 6:16

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  6. Content type: Research

    Blinatumomab has shown a remission rate of 69% in an exploratory single-arm, phase II dose-escalation study in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL). We evaluat...

    Authors: Virginie Nägele, Andrea Kratzer, Gerhard Zugmaier, Chris Holland, Youssef Hijazi, Max S. Topp, Nicola Gökbuget, Patrick A. Baeuerle, Peter Kufer, Andreas Wolf and Matthias Klinger

    Citation: Experimental Hematology & Oncology 2017 6:14

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  7. Content type: Case report

    Esophageal cancer including squamous cell carcinoma (SCC) and adenocarcinoma represents 4% of all cancers in the United States. Patients with esophageal cancer frequently present with locally advanced disease,...

    Authors: Natasha Garg, Constance Stoehr, Yan Shi Zhao, Heather Rojas and Chung-Tsen Hsueh

    Citation: Experimental Hematology & Oncology 2017 6:11

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  8. Content type: Review

    Refractory/relapsed B-cell acute lymphoblastic leukemia remains to be a significant cause of cancer-associated morbidity and mortality for children and adults. Developing novel and effective molecular-targeted...

    Authors: Guoqing Wei, Lijuan Ding, Jiasheng Wang, Yongxian Hu and He Huang

    Citation: Experimental Hematology & Oncology 2017 6:10

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  9. Content type: Case report

    Osteolytic bone lesions and hypercalcemia without peripheral blasts B-cell acute lymphoblastic leukemia (B-ALL) is reported in children but rarely seen in adults.

    Authors: Nikki Charlotta Paul Granacher, Zwi N. Berneman, Wilfried Schroyens, Ann L. R. Van de Velde, Anke Verlinden and Alain P. A. Gadisseur

    Citation: Experimental Hematology & Oncology 2017 6:9

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  10. Content type: Case report

    The BRAF K601E mutation occurs in 5% of patients with melanoma, and is the third most common type of BRAF mutation. However, treatment with BRAF and mitogen-activated extracellular signal-regulated kinase (MEK...

    Authors: Riccardo Marconcini, Luca Galli, Andrea Antonuzzo, Simona Bursi, Claudia Roncella, Gabriella Fontanini, Elisa Sensi and Alfredo Falcone

    Citation: Experimental Hematology & Oncology 2017 6:6

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  11. Content type: Research

    Chemotherapy-induced polyneuropathy (CIPN) is a common toxicity after chemotherapy, immunomodulatory drugs or proteasome inhibitors, which is difficult to treat and may also have impact on quality of life. The...

    Authors: Stefan S. Schönsteiner, Heidi Bauder Mißbach, Axel Benner, Silja Mack, Thomas Hamel, Michael Orth, Bernhard Landwehrmeyer, Sigurd D. Süßmuth, Carolin Geitner, Regine Mayer-Steinacker, Anneliese Riester, Andrea Prokein, Elfriede Erhardt, Jelena Kunecki, Anna M. Eisenschink, Rainer Rawer…

    Citation: Experimental Hematology & Oncology 2017 6:5

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  12. Content type: Case report

    Atypical hemolytic uremic syndrome is a rare disorder which is known to cause acute thrombotic microangiopathy during pregnancy with poor maternal and fetal outcomes. Atypical hemolytic uremic syndrome is cau...

    Authors: Gabriela Andries, Michael Karass, Srikanth Yandrapalli, Katherine Linder, Delong Liu, John Nelson, Rahul Pawar and Savneek Chugh

    Citation: Experimental Hematology & Oncology 2017 6:4

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  13. Content type: Case report

    The concept of precision medicine in cancer includes individual molecular studies to predict clinical outcomes. In the present N = 1 case we retrospectively have analysed lymphoma tissue by exome sequencing an...

    Authors: Julie Støve Bødker, Marianne Tang Severinsen, Tarec Christoffer El-Galaly, Rasmus Froberg Brøndum, Maria Bach Laursen, Steffen Falgreen, Mette Nyegaard, Alexander Schmitz, Lasse Hjort Jakobsen, Anna Amanda Schönherz, Hanne Due, Linn Reinholdt, Martin Bøgsted, Karen Dybkær and Hans Erik Johnsen

    Citation: Experimental Hematology & Oncology 2017 6:3

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  14. Content type: Research

    Leukemic and mesenchymal stem cells interact in the leukemic microenvironment and affect each other differently. This interplay has also important implications for the hematopoietic stem cell (HSC) biology and...

    Authors: Natalia-Del Pilar Vanegas and Jean-Paul Vernot

    Citation: Experimental Hematology & Oncology 2017 6:2

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  15. Content type: Case report

    Targeting BRAF V600E mutation has been proven effective in the treatment of several types of cancer. In endometrial adenocarcinoma, the BRAF V600E mutation has been rarely reported. Whether targeting BRAF onco...

    Authors: Michele Moschetta, Gabriel Mak, Joana Hauser, Catriona Davies, Mario Uccello and Hendrik-Tobias Arkenau

    Citation: Experimental Hematology & Oncology 2017 6:1

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  16. Content type: Short report

    Receptor tyrosine kinase, c-Kit (CD117) plays a pivotal role in the maintenance and expansion of hematopoietic stem/progenitor cells (HSPCs). Additionally, over-expression and/or mutational activation of c-Kit...

    Authors: Ningfei An, Bo Cen, Houjian Cai, Jin H. Song, Andrew Kraft and Yubin Kang

    Citation: Experimental Hematology & Oncology 2016 5:31

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  17. Content type: Review

    Breast cancer is the most frequent cause of cancer of women in much of the world. In countries with screening programs, breast cancer is often detected before clinical symptoms are apparent, but occasionally t...

    Authors: Ibrahim Fanous and Patrick Dillon

    Citation: Experimental Hematology & Oncology 2016 5:29

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  18. Content type: Research

    Pegylated-interferon alpha (PegINFα) treatment of patients with polycythemia vera (PV) and essential thrombocythemia (ET) has resulted in long-term clinical response, decreased JAK2 V61...

    Authors: Magdalena Kovacsovics-Bankowski, Todd W. Kelley, Olga Efimova, Soo Jin Kim, Andrew Wilson, Sabina Swierczek and Josef Prchal

    Citation: Experimental Hematology & Oncology 2016 5:28

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  19. Content type: Research

    The NAD(P)H: quinone oxidoreductase (NQO1) confers protection against semiquinones and also elicits oxidative stress. The C609T polymorphism of the NQO1 gene, designated NQO1*2, significantly reduces its enzymati...

    Authors: Joseph M. Wu, Ardalan Oraee, Barbara B. Doonan, John T. Pinto and Tze-chen Hsieh

    Citation: Experimental Hematology & Oncology 2016 5:27

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  20. Content type: Rapid communication

    Acute myeloid leukemia (AML) carrying nucleophosmin 1 (NPM1) mutations (NPMc+) is regarded as a separate entity of myeloid neoplasms due to its distinct biological and clinical features. However, NPMc+ alone disp...

    Authors: Hanna Grauers Wiktorin, Tina Nilsson, Ann Jansson, Lars Palmqvist and Anna Martner

    Citation: Experimental Hematology & Oncology 2016 5:25

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  21. Content type: Case report

    The increasing understanding of non-small cell lung cancer (NSCLC) biology over the last two decades has led to the identification of multiple molecular targets. This led to the development of multiple targete...

    Authors: David Berz, Victoria M. Raymond, Jordan H. Garst and Mark G. Erlander

    Citation: Experimental Hematology & Oncology 2016 5:24

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  22. Content type: Review

    With the rapid succession of new effective agents for melanoma in the recent years, the paradigm for treatment of metastatic melanoma is changing. The success of combining multiple effective agents compared wi...

    Authors: Eddy C. Hsueh and Kalyan C. Gorantla

    Citation: Experimental Hematology & Oncology 2016 5:23

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  23. Content type: Research

    Blocking mTOR (molecular target of rapamycin) by sirolimus has been shown to suppress cellular respiration. The bearing of this impaired cellular bioenergetics on the mode-of-action of mTOR inhibitors has yet ...

    Authors: Suleiman Al-Hammadi, Saeeda Almarzooqi, Alia Albawardi and Abdul-Kader Souid

    Citation: Experimental Hematology & Oncology 2016 5:22

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  24. Content type: Case report

    B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph′) is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph′+ is similar to B-ALL, but is more ...

    Authors: Bernardo López-Andrade, Francesca Sartori, Antonio Gutiérrez, Lucia García, Vanesa Cunill, María Antonia Durán, Antonia Sampol, Marta Bernués, Julio Iglesias, Rafael Ramos, Josep Lladó, María Sánchez, Juan Carlos Amat and Jordi Martínez-Serra

    Citation: Experimental Hematology & Oncology 2016 5:21

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  25. Content type: Case report

    The current standard of care for relapsed and refractory acute lymphoblastic leukemia (ALL) is combination chemotherapy.

    Authors: Katherine Linder, Deepthi Gandhiraj, Madhura Hanmantgad, Karen Seiter and Delong Liu

    Citation: Experimental Hematology & Oncology 2016 5:20

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  26. Content type: Review

    AMD3100, also known as plerixafor, was originally developed as an anti-human immunodeficiency virus (HIV) drug, and later characterized as a C-X-C chemokine receptor type 4 (CXCR4) antagonist. Previous reviews...

    Authors: Tao Liu, Xiaobo Li, Shuo You, Soumitra S. Bhuyan and Lei Dong

    Citation: Experimental Hematology & Oncology 2016 5:19

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  27. Content type: Letter to the Editor

    PTEN acts as a phosphatase for PIP3 and negatively regulates the PI3K/AKT pathway, and p27KIP1 is a cyclin-dependent kinase inhibitor that regulates the G1 to S-phase transition by binding to and regulating the a...

    Authors: Jingchen Shao, Susann Li, Lars Palmqvist, Linda Fogelstrand, Stella Y. Wei, Kiran Busayavalasa, Kui Liu and Viktor M. Liu

    Citation: Experimental Hematology & Oncology 2016 5:17

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  28. Content type: Case report

    Inflammatory breast cancer is a complex pathological entity associated with poor outcomes. This loco-regional disease is characterised by a rapid clinical course in the presence breast erythema and infiltratio...

    Authors: Piers R. Boshier, Rosie Sayers, Dimitri J. Hadjiminas, Charles Mackworth-Young, Susan Cleator and Daniel R. Leff

    Citation: Experimental Hematology & Oncology 2016 5:16

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  29. Content type: Review

    Hormonal manipulation plays a significant role in the treatment of advanced hormone naïve prostate cancer and castration-resistant prostate cancer (CRPC) with or without previous chemotherapy. Combination of g...

    Authors: Thy Pham, Martin C. Sadowski, Huika Li, Derek J. Richard, Michael C. d’Emden and Kerry Richard

    Citation: Experimental Hematology & Oncology 2016 5:15

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  30. Content type: Research

    Myeloproliferative neoplasms (MPNs) including the classic entities; polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis are rare diseases with unknown aetiology. The MOSAICC study,...

    Authors: Mary Frances McMullin, Glen James, Andrew S. Duncombe, Frank de Vocht, Lin Fritschi, Mike Clarke and Lesley A. Anderson

    Citation: Experimental Hematology & Oncology 2016 5:14

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  31. Content type: Case report

    Epstein–Barr virus-positive mucocutaneous ulcer (EBVMCU) is a recently recognized B cell lymphoproliferative disorder that is driven by latent EBV infection and causes discrete ulcerations in the oropharynx, g...

    Authors: Toni K. Roberts, Xueyan Chen and Jay Justin Liao

    Citation: Experimental Hematology & Oncology 2016 5:13

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  32. Content type: Research

    Dys-megakaryopoiesis is defined as ≥10 % of dysplastic megakaryocytes in bone marrow smears by the World Health Organization. However, concordance rates for dysplastic megakaryocytes between different observer...

    Authors: Gege Feng, Robert Peter Gale, Wen Cui, Wenyu Cai, Gang Huang, Zefeng Xu, Tiejun Qin, Yue Zhang, Bing Li, Liwei Fang, Hongli Zhang, Lijuan Pan, Naibo Hu, Shiqiang Qu, Jingya Wang, Yajuan Cui…

    Citation: Experimental Hematology & Oncology 2016 5:12

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  33. Content type: Research

    The immunomodulatory agent pomalidomide in combination with low-dose dexamethasone has demonstrated efficacy and safety for the treatment of relapsed and refractory multiple myeloma (RRMM) in phase 2 and 3 tri...

    Authors: Tatsuo Ichinohe, Yoshiaki Kuroda, Shinichiro Okamoto, Kosei Matsue, Shinsuke Iida, Kazutaka Sunami, Takuya Komeno, Kenshi Suzuki, Kiyoshi Ando, Masafumi Taniwaki, Kensei Tobinai, Takaaki Chou, Hitomi Kaneko, Hiromi Iwasaki, Chie Uemura, Hiromi Tamakoshi…

    Citation: Experimental Hematology & Oncology 2016 5:11

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  34. Content type: Erratum

    Authors: Clémentine Gamonet, Elodie Bole-Richard, Aurélia Delherme, François Aubin, Eric Toussirot, Francine Garnache-Ottou, Yann Godet, Loïc Ysebaert, Olivier Tournilhac, Caroline Dartigeas, Fabrice Larosa, Eric Deconinck, Philippe Saas, Christophe Borg, Marina Deschamps and Christophe Ferrand

    Citation: Experimental Hematology & Oncology 2016 5:10

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    The original article was published in Experimental Hematology & Oncology 2016 5:7

  35. Content type: Case report

    The chromosomal translocation t(11;19)(q23;p13) with a breakpoint within subband 19p13.1 is found mainly in acute myeloid leukemia (AML) and results in the MLL-ELL fusion gene. Variations in the structure of MLL-

    Authors: Ioannis Panagopoulos, Ludmila Gorunova, Gitte Kerndrup, Signe Spetalen, Anne Tierens, Liv T. N. Osnes, Kristin Andersen, Lil-Sofie Ording Müller, Marit Hellebostad, Bernward Zeller and Sverre Heim

    Citation: Experimental Hematology & Oncology 2016 5:8

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  36. Content type: Research

    CD20 is a B cell lineage–specific marker expressed by normal and leukemic B cells and targeted by several antibody immunotherapies. We have previously shown that the protein from a CD20 mRNA splice variant (D3...

    Authors: Clémentine Gamonet, Elodie Bole-Richard, Aurélia Delherme, François Aubin, Eric Toussirot, Francine Garnache-Ottou, Yann Godet, Loïc Ysebaert, Olivier Tournilhac, Caroline Dartigeas, Fabrice Larosa, Eric Deconinck, Philippe Saas, Christophe Borg, Marina Deschamps and Christophe Ferrand

    Citation: Experimental Hematology & Oncology 2016 5:7

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    The Erratum to this article has been published in Experimental Hematology & Oncology 2016 5:10

  37. Content type: Research

    The causative link between UV exposure and melanoma development is well known, however the mechanistic relationship remains incompletely characterised. UVA and UVB components of sunlight are implicated in mela...

    Authors: Heather C. Murray, Vicki E. Maltby, Doug W. Smith and Nikola A. Bowden

    Citation: Experimental Hematology & Oncology 2016 5:6

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  38. Content type: Rapid communication

    Proteostasis is defined by the orchestrated control of anabolic and catabolic protein pathways. Disruption of proteostasis results in cell stress and adaptation to proteostasis imbalance is mediated by adaptiv...

    Authors: Margherita Vieri, Huimin Geng, John B. Patterson, Jens Panse, Stefan Wilop, Afshin Samali, Eric Chevet and Behzad Kharabi Masouleh

    Citation: Experimental Hematology & Oncology 2016 5:5

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  39. Content type: Research

    Dysregulation of miRNAs that can act as tumor suppressors or oncogenes can result in tumorigenesis. Previously we demonstrated that miR-199b was significantly downregulated in acute myeloid leukemia (AML) and ...

    Authors: Amanda J. Favreau, Rose E. McGlauflin, Christine W. Duarte and Pradeep Sathyanarayana

    Citation: Experimental Hematology & Oncology 2016 5:4

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  40. Content type: Research

    Hydroxyurea (HU) is among the most commonly used cytoreductive treatments for polycythemia vera (PV), but previous research and clinical experience suggest that not all patients respond optimally, consistently...

    Authors: Shreekant Parasuraman, Marco DiBonaventura, Kelly Reith, Ahmad Naim, Kristen Concialdi and Nicholas J. Sarlis

    Citation: Experimental Hematology & Oncology 2016 5:3

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