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  1. The past decade has witnessed ongoing progress in immune therapy to ameliorate human health. As an emerging technique, chimeric antigen receptor (CAR) T-cell therapy has the advantages of specific killing of c...

    Authors: Ting Yan, Lingfeng Zhu and Jin Chen
    Citation: Experimental Hematology & Oncology 2023 12:14
    Content type: Review Published on:

  2. CD8+ T cells play an essential role against tumors but the role of human CD8+CD26+ T cell subset against tumors, in particular, haematological cancers such as chronic lymphocytic leukemia (CLL) remains unknown. A...

    Authors: Najmeh Bozorgmehr, Mark Hnatiuk, Anthea C. Peters and Shokrollah Elahi
    Citation: Experimental Hematology & Oncology 2023 12:13
    Content type: Research Published on:

  3. Circular RNAs (circRNAs) are emerging as new players in leukemogenic mechanisms. In patients with T-cell Acute Lymphoblastic Leukemia (T-ALL), the recent report of a remarkable dysregulation of circRNAs incite...

    Authors: Alessia Buratin, Cristina Borin, Caterina Tretti Parenzan, Anna Dal Molin, Silvia Orsi, Andrea Binatti, Katharina Simon, Maddalena Paganin, Valentina Serafin, Enrico Gaffo, Geertruij te Kronnie, Pieter Van Vlierberghe, Silvia Bresolin and Stefania Bortoluzzi
    Citation: Experimental Hematology & Oncology 2023 12:12
    Content type: Correspondence Published on:

  4. Adult hematopoietic stem cells (HSCs) homeostasis is critically important in maintaining lifelong hematopoiesis. However, how adult HSCs orchestrate its homeostasis remains not fully understood. Imprinted gene...

    Authors: Deyu Huang, Yingli Han, Tian Tang, Lin Yang, Penglei Jiang, Wenchang Qian, Zhaoru Zhang, Xinyue Qian, Xin Zeng and Pengxu Qian
    Citation: Experimental Hematology & Oncology 2023 12:11
    Content type: Research Published on:

  5. Immunotherapy has become the central pillar of cancer therapy. Immune checkpoint inhibitors (ICIs), a major category of tumor immunotherapy, reactivate preexisting anticancer immunity. Initially, ICIs were app...

    Authors: Weijie Ma, Ruobing Xue, Zheng Zhu, Hizra Farrukh, Wenru Song, Tianhong Li, Lei Zheng and Chong-xian Pan
    Citation: Experimental Hematology & Oncology 2023 12:10
    Content type: Review Published on:

  6. Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumors. Cell division cycle associated 8 (CDCA8) is an important multifactorial regulator in cancers. However, its up and downstream targets a...

    Authors: Erbao Chen, Yu He, Jing Jiang, Jing Yi, Zhilin Zou, Qiuzi Song, Qingqi Ren, Zewei Lin, Yi Lu, Jikui Liu and Jian Zhang
    Citation: Experimental Hematology & Oncology 2023 12:9
    Content type: Research Published on:

  7. In this study, we established a novel immunologic gene prognostic index (IGPI) to predict metastasis and provided new insights into tumor immune microenvironment (TIME) for PCa patients receiving radical radio...

    Authors: Dechao Feng, Weizhen Zhu, Xu Shi, Zhihong Wang, Wuran Wei, Qiang Wei, Lu Yang and Ping Han
    Citation: Experimental Hematology & Oncology 2023 12:8
    Content type: Correspondence Published on:

  8. Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-...

    Authors: Zhihua Gong, Qingzhu Jia, Jinming Guo, Chongyi Li, Shouxia Xu, Zheng Jin, Han Chu, Yisong Y. Wan, Bo Zhu and Yi Zhou
    Citation: Experimental Hematology & Oncology 2023 12:7
    Content type: Research Published on:

  9. Cytidine triphosphate synthase 2 (CTPS2) is an essential metabolic enzyme that catalyzes the biosynthesis of CTP. CTP synthases contribute to lymphocytes proliferation and tumorigenesis, but the role of CTPS2 ...

    Authors: Xinting Hu, Yang Han, Jiarui Liu, Hua Wang, Zheng Tian, Xin Zhang, Ya Zhang and Xin Wang
    Citation: Experimental Hematology & Oncology 2023 12:6
    Content type: Research Published on:

  10. T-cell acute lymphoblastic leukemia (T-ALL) is a challenging pediatric and adult haematologic disease still associated with an unsatisfactory cure rate. Unlike B-ALL, the availability of novel therapeutic opti...

    Authors: Daniele Caracciolo, Antonia Mancuso, Nicoletta Polerà, Caterina Froio, Giuseppe D’Aquino, Caterina Riillo, Pierosandro Tagliaferri and Pierfrancesco Tassone
    Citation: Experimental Hematology & Oncology 2023 12:5
    Content type: Review Published on:

  11. αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines ...

    Authors: Behnam Rashidieh, Amanda Louise Bain, Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart, Jacinta Ley Simmons, Pirjo M. Apaja, Pascal H. G. Duijf, John Finnie and Kum Kum Khanna
    Citation: Experimental Hematology & Oncology 2023 12:4
    Content type: Research Published on:

  12. Breast cancer heterogeneity determines cancer progression, treatment effects, and prognosis. However, the precise mechanism for this heterogeneity remains unknown owing to its complexity. Here, we summarize th...

    Authors: Liantao Guo, Deguang Kong, Jianhua Liu, Ling Zhan, Lan Luo, Weijie Zheng, Qingyuan Zheng, Chuang Chen and Shengrong Sun
    Citation: Experimental Hematology & Oncology 2023 12:3
    Content type: Review Published on:

  13. Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal inflammatory clinical condition, in which an exaggerated immune response is ineffectively regulated. Although etoposide-containing regimens are g...

    Authors: Timo C. E. Zondag, Aglina Lika and Jan A. M. van Laar
    Citation: Experimental Hematology & Oncology 2023 12:2
    Content type: Correspondence Published on:

  14. N6-methyladenosine (m6A) is a prevalent modification of mRNA and is known to play important roles in tumorigenesis in many types of cancer. The function of N6-methyladenosine (m6A) RNA methylation depends on a...

    Authors: Weijian Wang, Qibo Huang, Zhibin Liao, Hongwei Zhang, Yachong Liu, Furong Liu, Xiaoping Chen, Bixiang Zhang, Yan Chen and Peng Zhu
    Citation: Experimental Hematology & Oncology 2023 12:1
    Content type: Research Published on:

  15. The treatment landscape of classical Hodgkin lymphoma (cHL) has undergone significant changes over the past 20 years. Gradual improvements have been made in the management of cHL patients, particularly in prol...

    Authors: Walter Hanel, Alex F. Herrera and Narendranath Epperla
    Citation: Experimental Hematology & Oncology 2022 11:108
    Content type: Review Published on:

  16. Breast cancer is the most common malignancy and the second leading cause of cancer-related death in women. Recent studies have indicated that aberrant activation of Rho GTPases relates to the malignant propert...

    Authors: Ming Yi, Di Zhang, Bin Song, Bin Zhao, Mengke Niu, Yuze Wu, Zhijun Dai and Kongming Wu
    Citation: Experimental Hematology & Oncology 2022 11:107
    Content type: Research Published on:

  18. Brain metastasis accounts for a large number of cancer-related deaths. The host immune system, involved at each step of the metastatic cascade, plays an important role in both the initiation of the brain metas...

    Authors: Wei-Wei Chen, Timothy Shun Man Chu, LiangLiang Xu, Cai-Ning Zhao, Wai-Sang Poon, Gilberto Ka-Kit Leung and Feng-Ming (Spring) Kong
    Citation: Experimental Hematology & Oncology 2022 11:105
    Content type: Review Published on:

  19. Breast cancer is one the most common cause of cancer death in women worldwide. We report here the first phase II study investigating a virus genetically engineered for tumor-selective replication in patients w...

    Authors: Sophie Cousin, Maud Toulmonde, Michèle Kind, Jean-Philippe Guegan, Alban Bessede, Coralie Cantarel, Carine Bellera and Antoine Italiano
    Citation: Experimental Hematology & Oncology 2022 11:104
    Content type: Correspondence Published on:

  20. Acute promyelocytic leukemia (APL) is highly aggressive and is frequently associated with disseminated intravascular coagulation and high early death rates. Although all-trans retinoic acid (RA) induces comple...

    Authors: Xubo Gong, Piaoping Kong, Teng Yu, Xibin Xiao, Lin Wang, Yiwen Sang, Xiang Li, Bin Zhang, Zhihua Tao and Weiwei Liu
    Citation: Experimental Hematology & Oncology 2022 11:103
    Content type: Correspondence Published on:

  21. Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains...

    Authors: Chen Wang, Taiyang Ye, Wenjing Wang, Keqi Song, Jie Zhu, Lan Dai and Wen Di
    Citation: Experimental Hematology & Oncology 2022 11:102
    Content type: Correspondence Published on:

  22. Programmed cell death protein 1(PD-1) is a type of immune-inhibitory checkpoint protein, which delivers inhibitory signals to cytotoxic T cells by binding to the programmed death ligand-1 (PD-L1) displayed on ...

    Authors: Mengyuan Dai, Miao Liu, Hua Yang, Can Küçük and Hua You
    Citation: Experimental Hematology & Oncology 2022 11:101
    Content type: Review Published on:

    The Publisher Correction to this article has been published in Experimental Hematology & Oncology 2022 11:106

  24. Neutrophil extracellular traps (NETs) released by activated neutrophils typically consist of DNA-histone complexes and granule proteins. NETs were originally identified as a host defense system against foreign...

    Authors: Yue Chen, Haoyue Hu, Songtao Tan, Qionglan Dong, Xue Fan, Yi Wang, Huan Zhang and Jun He
    Citation: Experimental Hematology & Oncology 2022 11:99
    Content type: Review Published on:

  25. Uterine and ovarian cancers are the most common gynecologic cancers. N6−methyladenosine (m6A), an important internal RNA modification in higher eukaryotes, has recently become a hot topic in epigenetic studies. N...

    Authors: Jiahua Chen, Bao Guo, Xiaojing Liu, Jing Zhang, Junhui Zhang, Yuan Fang, Suding Zhu, Bing Wei, Yunxia Cao and Lei Zhan
    Citation: Experimental Hematology & Oncology 2022 11:98
    Content type: Review Published on:

  26. Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but also participates in the development and progression of cancer. In recent decades, extensive efforts have been made t...

    Authors: Yiyang Liu, Yufei Wang, Sheng Sun, Zeyu Chen, Shuai Xiang, Zeyang Ding, Zhao Huang and Bixiang Zhang
    Citation: Experimental Hematology & Oncology 2022 11:97
    Content type: Review Published on:

  27. Acute graft-versus-host disease (aGVHD), especially intestinal aGVHD, is one of the most severe complications after allogeneic hematopoietic stem cell transplantation (HSCT). Fecal microbiota transplantation (...

    Authors: Yin Liu, Ye Zhao, Jiaqian Qi, Xiao Ma, Xiaofei Qi, Depei Wu and Yang Xu
    Citation: Experimental Hematology & Oncology 2022 11:96
    Content type: Correspondence Published on:

  28. Vitreoretinal lymphoma (VRL) is strongly linked to central nervous system (CNS) progression with no standard treatment approaches. Commonly used strategies include repeated intraocular injections of low-dose m...

    Authors: Wenxue Guan, Liang Wang and Xiaoyan Peng
    Citation: Experimental Hematology & Oncology 2022 11:95
    Content type: Correspondence Published on:

  29. While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy. Thus, there i...

    Authors: Gus O. Nwosu, Jason A. Powell and Stuart M. Pitson
    Citation: Experimental Hematology & Oncology 2022 11:94
    Content type: Review Published on:

  30. Cancer is one of the leading causes of death worldwide due to high heterogeneity. Although chemotherapy remains the mainstay of cancer therapy, non-selective toxicity and drug resistance of mono-chemotherapy i...

    Authors: Mo Wu, Wei Huang, Nan Yang and Yanyong Liu
    Citation: Experimental Hematology & Oncology 2022 11:93
    Content type: Review Published on:

  31. Though circular RNAs (circRNAs) are the key regulators in tumor carcinogenesis, they remain largely unexplored in hepatocellular carcinoma (HCC).

    Authors: Xia-Hui Lin, Zhi-Yong Liu, Dan-Ying Zhang, Si Zhang, Wen-Qing Tang, Dong-Ping Li, Feng Zhang, Rong-Xin Chen, Shu-Qiang Weng, Ru-Yi Xue and Ling Dong
    Citation: Experimental Hematology & Oncology 2022 11:92
    Content type: Research Published on:

  32. RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proli...

    Authors: Tiantian Wang, Dean Rao, Chengpeng Yu, Jiaqi Sheng, Yiming Luo, Limin Xia and Wenjie Huang
    Citation: Experimental Hematology & Oncology 2022 11:91
    Content type: Review Published on:

  34. Aberrant DNA methylation (DNAm) is an important epigenetic regulator in various cancers. Pan-cancer DNAm analyses have investigated the potential common mechanisms of DNAm in tumorigenesis. However, these pan-...

    Authors: Zheng Dong and Hongyu Zhou
    Citation: Experimental Hematology & Oncology 2022 11:89
    Content type: Correspondence Published on:

  35. Accumulating evidence implicates that gut fungi are associated with the pathogenesis of colorectal cancer (CRC). Our previous study has revealed that Candida tropicalis (C. tropicalis) promotes colorectal tumorig...

    Authors: Zhiyong Zhang, Yaojun Zheng, Ying Chen, Yuxin Yin, Yuxi Chen, Qianyu Chen, Yayi Hou, Sunan Shen, Mingming Lv and Tingting Wang
    Citation: Experimental Hematology & Oncology 2022 11:88
    Content type: Research Published on:

  36. Pseudogenes play an essential role in tumor occurrence and progression. However, the functions and mechanisms of pseudogenes in clear cell renal cell carcinoma (ccRCC) remain largely elusive.

    Authors: Lei Yang, Haoli Yin, Yi Chen, Chun Pan, Hexing Hang, Yanwen Lu, Wenliang Ma, Xin Li, Weidong Gan, Hongqian Guo and Dongmei Li
    Citation: Experimental Hematology & Oncology 2022 11:87
    Content type: Research Published on:

  37. Acute lymphoblastic leukemia is the most common childhood malignancy. One of the drugs used in the treatment is Asparaginase, and monitoring of its activity levels enables better outcomes. Since 2018, our labo...

    Authors: Daiane Keller Cecconello, Ciliana Rechenmacher, Klerize Anecely de Souza Silva, Fernanda Fetter Scherer, Thomas Dal Bem Prates, Rebeca Ferreira Marques, Liane Esteves Daudt and Mariana Bohns Michalowski
    Citation: Experimental Hematology & Oncology 2022 11:86
    Content type: Correspondence Published on:

  38. Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent achievement in the clinical immunotherapy of hematological malignant tumors, leading to a rapid development of cellular immuno...

    Authors: Xiao Wang, Xuejiao Yang, Xiang Yuan, Wenbo Wang and Yueying Wang
    Citation: Experimental Hematology & Oncology 2022 11:85
    Content type: Review Published on:

  39. The lymphatic vascular system represents a major route for dissemination of several solid tumors, including melanoma. Even though the members of the Vascular Endothelial Growth Factor family VEGF-C and VEGF-A ...

    Authors: Marta Turati, Arianna Giacomini, Sara Rezzola, Federica Maccarinelli, Giorgia Gazzaroli, Sonia Valentino, Barbara Bottazzi, Marco Presta and Roberto Ronca
    Citation: Experimental Hematology & Oncology 2022 11:84
    Content type: Correspondence Published on:

  40. Thioredoxin-1 (TXN1) is one of the major cellular antioxidants in mammals and is involved in a wide range of physiological cellular responses. However, little is known about the roles and the underlying molecu...

    Authors: Shaima Jabbar, Parker Mathews, Xiaobei Wang, Pasupathi Sundaramoorthy, Emily Chu, Sadhna O. Piryani, Shengli Ding, Xiling Shen, Phuong L. Doan and Yubin Kang
    Citation: Experimental Hematology & Oncology 2022 11:83
    Content type: Research Published on:

  41. Since U.S. President Barack Obama announced the Precision Medicine Initiative in his New Year’s State of the Union address in 2015, the establishment of a precision medicine system has been emphasized worldwid...

    Authors: Ryuji Hamamoto, Takafumi Koyama, Nobuji Kouno, Tomohiro Yasuda, Shuntaro Yui, Kazuki Sudo, Makoto Hirata, Kuniko Sunami, Takashi Kubo, Ken Takasawa, Satoshi Takahashi, Hidenori Machino, Kazuma Kobayashi, Ken Asada, Masaaki Komatsu, Syuzo Kaneko…
    Citation: Experimental Hematology & Oncology 2022 11:82
    Content type: Review Published on:

  42. The bone marrow microenvironment of acute myeloid leukemia (AML) consists of various cell types and signaling factors, which serve as a niche supporting leukemia cells in their invasion of the human body. Howe...

    Authors: Binyan Xu, Ziying Zhou, Yueting Wen, Zhongwei Li, Zhongxi Huang and Yuhua Li
    Citation: Experimental Hematology & Oncology 2022 11:81
    Content type: Correspondence Published on:

  43. RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease. RBPs influence the fate of mRNAs through multiple mechanis...

    Authors: Tiffany M. Tran and Dinesh S. Rao
    Citation: Experimental Hematology & Oncology 2022 11:80
    Content type: Review Published on:

  44. Cancer-associated thrombosis (CAT) poses a significant disease burden and the incidence in Asian populations is increasing. Anticoagulation is the cornerstone of treatment, but can be challenging due to the hi...

    Authors: Lai Heng Lee, Pongwut Danchaivijitr, Noppacharn Uaprasert, Harinder Gill, Dennis Lee Sacdalan, Gwo Fuang Ho, Rajiv Parakh, Paresh Pai, Jen-Kuang Lee, Nannette Rey and Alexander T. Cohen
    Citation: Experimental Hematology & Oncology 2022 11:79
    Content type: Review Published on:

  45. Camrelizumab (SHR-1210) is a humanized IgG4 monoclonal anti-programmed cell death protein 1 (PD-1) antibody that has been shown to inhibit the binding of PD-1 to PD-L1, thereby blocking the immune escape of va...

    Authors: Rong Ma, Jia-Lin Wang and Yan-Yang Wang
    Citation: Experimental Hematology & Oncology 2022 11:78
    Content type: Correspondence Published on:

  46. Glucose-6-phosphate dehydrogenase (G6PD) as the rate-limiting enzyme in the pentose phosphate pathway (PPP) is well-established as an aberrantly expressed protein in numerous clinical diseases; however, its ro...

    Authors: Rui Li, Mengying Ke, Mingming Qi, Zhenru Han, Yuhao Cao, Zhendong Deng, Jinjun Qian, Ye Yang and Chunyan Gu
    Citation: Experimental Hematology & Oncology 2022 11:77
    Content type: Research Published on:

  47. Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore that is required for proper chromosomal segregation and cell division. However, little i...

    Authors: Dechao Feng, Weizhen Zhu, Xu Shi, Qiao Xiong, Dengxiong Li, Wuran Wei, Ping Han, Qiang Wei and Lu Yang
    Citation: Experimental Hematology & Oncology 2022 11:76
    Content type: Correspondence Published on:

  48. The tripartite-motif (TRIM) family represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular signaling transductions an...

    Authors: Ning Huang, Xiaolin Sun, Peng Li, Xin liu, Xuemei Zhang, Qian Chen and Hong Xin
    Citation: Experimental Hematology & Oncology 2022 11:75
    Content type: Review Published on:

  49. Acute myeloid leukemia (AML) is a complex, heterogeneous malignant hematologic disease. Although multiple prognostic-related genes gave been explored in previous studies, there are still many genes whose progn...

    Authors: Xueqian Li, Jiaqian Qi, Xiaofei Song, Xiaoyan Xu, Tingting Pan, Hong Wang, Jingyi Yang and Yue Han
    Citation: Experimental Hematology & Oncology 2022 11:74
    Content type: Correspondence Published on:

  50. Long-term outcome is unfavourable for relapsed/refractory (r/r) lymphoma patients who are resistant to salvage chemotherapy, even after subsequent autologous stem-cell transplantation (ASCT). Although anti-CD3...

    Authors: Peiling Zhang, Xiuxiu Yang, Yang Cao, Jue Wang, Mi Zhou, Liting Chen, Jia Wei, Zekai Mao, Di Wang, Yi Xiao, Haichuan Zhu, Shangkun Zhang, Tongcun Zhang, Yicheng Zhang, Jianfeng Zhou and Liang Huang
    Citation: Experimental Hematology & Oncology 2022 11:72
    Content type: Research Published on:
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