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  1. Content type: Research

    We investigated the safety and antitumor activity of dalotuzumab, a selective anti-insulin growth factor 1 receptor monoclonal antibody (IGF1R MoAb), plus erlotinib in a sequential phase I/II trial in unselect...

    Authors: Teresa Moran, Enriqueta Felip, Vicki Keedy, Hossein Borghaei, Frances A Shepherd, Amelia Insa, Holly Brown, Timothy Fitzgerald, Sriram Sathyanarayanan, John F Reilly, David Mauro, Karl Hsu, Li Yan and David H Johnson

    Citation: Experimental Hematology & Oncology 2014 3:1

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  2. Content type: Research

    Tobacco, alcohol and HPV infection are associated with increased risk of HNSCC. However, little is known about the underlying signaling events influencing risk. We aimed to investigate the relationship between...

    Authors: Mohammad R Islam, Ian R Ellis, Michaelina Macluskey, Lynda Cochrane and Sarah J Jones

    Citation: Experimental Hematology & Oncology 2014 3:25

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  3. Content type: Research

    Cholesterol plays an important role in cancer development, drug resistance and chemoimmuno-sensitivity. Statins, cholesterol lowering drugs, can induce apoptosis, but also negatively interfere with CD-20 and r...

    Authors: Indira Benakanakere, Tyler Johnson, Richard Sleightholm, Virgilio Villeda, Monika Arya, Ravi Bobba, Carl Freter and Chunfa Huang

    Citation: Experimental Hematology & Oncology 2014 3:24

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  4. Content type: Short report

    Hormone-refractory breast cancer metastatic to bone is a clinically challenging disease associated with high morbidity, poor prognosis, and impaired quality of life owing to pain and skeletal-related events. I...

    Authors: Amol Takalkar, Scott Adams and Vivek Subbiah

    Citation: Experimental Hematology & Oncology 2014 3:23

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  5. Content type: Research

    Little is known about the epidemiology of MDS in minority populations. The IPSS and newly released IPSS-R are important clinical tools in prognostication of patients with MDS. Therefore, we conducted a retrosp...

    Authors: Ashwin Sridharan, Rishi Jain, Marcus A Bachhuber, Yiting Yu, KH Ramesh, Krishna Gundabolu, Ellen W Friedman and Amit K Verma

    Citation: Experimental Hematology & Oncology 2014 3:22

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  6. Content type: Case report

    Acquired hemophilia A (AHA) and acquired von Willebrand Syndrome (AVWS) are both rare bleeding disorders that can be associated with lymphoproliferative or autoimmune diseases. AHA is uniformly caused by inhib...

    Authors: Christina Dicke, Katharina Holstein, Sonja Schneppenheim, Rita Dittmer, Reinhard Schneppenheim, Carsten Bokemeyer, Christof Iking-Konert, Ulrich Budde and Florian Langer

    Citation: Experimental Hematology & Oncology 2014 3:21

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  7. Content type: Case report

    Neuroblastoma is considered a pediatric malignancy as over 95% of cases are diagnosed in patients ≤10 years old. This cancer is extremely rare in elderly patients. We conducted a Surveillance, Epidemiology, an...

    Authors: Elisa Rogowitz, Hani M Babiker, Mohammed Kanaan, Rebecca A Millius, Q Scott Ringenberg and Maria Bishop

    Citation: Experimental Hematology & Oncology 2014 3:20

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  8. Content type: Erratum

    Citation: Experimental Hematology & Oncology 2014 3:19

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    The original article was published in Experimental Hematology & Oncology 2014 3:10

  9. Content type: Rapid communication

    Systemic mastocytosis (SM) is a heterogenous, clonal mast cell (MC) proliferation, rarely associated with clonal hematologic non-mast cell lineage disease (SM-AHNMD). KITD816V is regarded as driver-mutation in SM...

    Authors: Markus Rechsteiner, Rouven Müller, Tanja Reineke, Jeroen Goede, Annette Bohnert, Qing Zhong, Markus G Manz, Holger Moch, Peter J Wild, Dieter R Zimmermann and Marianne Tinguely

    Citation: Experimental Hematology & Oncology 2014 3:18

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  10. Content type: Research

    The miR-29 family have been demonstrated acting as vital tumor suppressor in multiple cancers as well as regulators in the adaptive immune system. Little is known about their role in leukemogenesis. The purpos...

    Authors: Ling Xu, Yan Xu, Zhenyi Jing, Xu Wang, Xianfeng Zha, Chengwu Zeng, Shaohua Chen, Lijian Yang, Gengxin Luo, Bo Li and Yangqiu Li

    Citation: Experimental Hematology & Oncology 2014 3:17

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  11. Content type: Review

    In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy, as well as the leading cause of childhood cancer-related mortality. Advances in cyt...

    Authors: Jennifer S Woo, Michael O Alberti and Carlos A Tirado

    Citation: Experimental Hematology & Oncology 2014 3:16

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  12. Content type: Case report

    A 91-year-old woman affected with acquired Von Willebrand (VW) syndrome and intestinal angiodysplasias presented with severe gastrointestinal bleeding (hemoglobin 5 g/dl). Despite replacement therapy with VW f...

    Authors: Massimo Cugno, Alberto Tedeschi, Simona Maria Siboni, Francesca Stufano, Federica Depetri, Franca Franchi, Samantha Griffini and Flora Peyvandi

    Citation: Experimental Hematology & Oncology 2014 3:15

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  13. Content type: Review

    Recently, whole genome sequencing approaches have pinpointed mutations in genes that were previously not associated with cancer. For Acute Myeloid Leukaemia (AML), and other myeloid disorders, these approaches...

    Authors: Bryony Leeke, Judith Marsman, Justin M O’Sullivan and Julia A Horsfield

    Citation: Experimental Hematology & Oncology 2014 3:13

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  14. Content type: Research

    Mesothelin, a mesothelial marker, has been found expressed in and as a potential treatment target of cholangioacarcinoma (CC). It is possible that CC may be derived from the cells sharing mesothelial markers. ...

    Authors: Lanjing Zhang, Renee Frank, Emma E Furth, Amy F Ziober, Virginia A LiVolsi and Paul J Zhang

    Citation: Experimental Hematology & Oncology 2014 3:12

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  15. Content type: Research

    Recombinant human interleukin 12 (rHuIL-12) regulates hematopoiesis and cell-mediated immunity. Based on these hematopoietic and immunomodulatory activities, a recombinant human IL-12 (rHuIL-12) is now under d...

    Authors: Mamata S Gokhale, Vladimir Vainstein, Jamie Tom, Simmy Thomas, Chris E Lawrence, Zoya Gluzman-Poltorak, Nicholas Siebers and Lena A Basile

    Citation: Experimental Hematology & Oncology 2014 3:11

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  16. Content type: Research

    This study examined patient outcomes using real world data for acute myeloid leukemia (AML) patients initiating treatment.

    Authors: B Douglas Smith, Charles L Beach, Dalia Mahmoud, Laura Weber and Henry J Henk

    Citation: Experimental Hematology & Oncology 2014 3:10

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    The Erratum to this article has been published in Experimental Hematology & Oncology 2014 3:19

  17. Content type: Research

    Arsenic trioxide (ATO) is a novel form of therapy that has been found to aid acute promyelocytic leukemia (APL) patients. Our laboratory has demonstrated that ATO-induced cytotoxicity in human leukemia (HL-60)...

    Authors: Christian S Rogers, Clement G Yedjou, Dwayne J Sutton and Paul B Tchounwou

    Citation: Experimental Hematology & Oncology 2014 3:9

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  18. Content type: Case report

    The gene RUNX1 at chromosome 21q22 encodes the alpha subunit of Core binding factor (CBF), a heterodimeric transcription factor involved in the development of normal hematopoiesis. Translocations of RUNX1 are see...

    Authors: Jianling Ji, Eric Loo, Sheeja Pullarkat, Lynn Yang and Carlos A Tirado

    Citation: Experimental Hematology & Oncology 2014 3:8

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  19. Content type: Research

    Those stimuli that together promote the survival, differentiation and proliferation of the abnormal B-lymphocytes of chronic lymphocytic leukaemia (CLL) are encountered within tissues, where together they form...

    Authors: Claire V Hutchinson, Shiva Natarajan, Suzanne M Johnson, Julie A Adams, Karen S Rees-Unwin and John Burthem

    Citation: Experimental Hematology & Oncology 2014 3:7

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  20. Content type: Case report

    Here we report on a case of Philadelphia chromosome positive B lymphoblastic leukemia (Ph+ALL), which developed following a long duration of essential thrombocythemia (ET). A mutational analysis of Janus Kinase 2...

    Authors: Yuya Nagai, Masahiro Kawahara, Noriko Sugino, Yayoi Shimazu, Masakatsu Hishizawa, Kouhei Yamashita, Norimitsu Kadowaki and Akifumi Takaori-Kondo

    Citation: Experimental Hematology & Oncology 2014 3:6

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  21. Content type: Research

    Combination of phenethyl isothiocyanate (PEITC) and paclitaxel (taxol) has been shown to work synergistically to increase apoptosis and cell cycle arrest in breast cancer cells. In this report, we further expl...

    Authors: Shundong Cang, Yuehua Ma, Jen-wei Chiao and Delong Liu

    Citation: Experimental Hematology & Oncology 2014 3:5

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  22. Content type: Review

    Research over the role of Bruton’s agammaglobulinemia tyrosine kinase (BTK) in B-lymphocyte development, differentiation, signaling and survival has led to better understanding of the pathogenesis of B-cell ma...

    Authors: Aileen Novero, Pavan M Ravella, Yamei Chen, George Dous and Delong Liu

    Citation: Experimental Hematology & Oncology 2014 3:4

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  23. Content type: Research

    The host’s immune system is crucially involved in cancer development and progression. The ratio of regulatory to effector T-cells, as well as the interplay of T-cells with therapeutic agents, impact on cancer ...

    Authors: Anna Koumarianou, Maria-Ioanna Christodoulou, Pavlos Patapis, Iordanis Papadopoulos, Elissavet Liakata, Athina Giagini, Anastasia Stavropoulou, Nikiforita Poulakaki, Nikolaos Tountas, Nikolaos Xiros, Theophanis Economopoulos, Dimitris Pectasides, Ourania E Tsitsilonis and Vassiliki Pappa

    Citation: Experimental Hematology & Oncology 2014 3:3

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  24. Content type: Letter to the Editor

    We analyze the epidemiological characteristics and outcomes of 72 patients diagnosed with non-metastatic inflammatory breast cancer (IBC) at National Institute of Oncology of Rabat in Morocco, between January ...

    Authors: Nabil Ismaili, Hind Elyaakoubi, Youssef Bensouda and Hassan Errihani

    Citation: Experimental Hematology & Oncology 2014 3:1

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  25. Content type: Review

    The immune system is the built-in host defense mechanism against infectious agents as well as cancer. Protective immunity against cancer was convincingly demonstrated in the 1940s with syngeneic animal models ...

    Authors: Zihai Li, Lieping Chen and Mark P Rubinstein

    Citation: Experimental Hematology & Oncology 2013 2:33

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  26. Content type: Research

    Everolimus and sunitinib have been approved for the treatment advanced pancreatic neuroendocrine tumors, but have not been compared to each other in a randomized trial and have not demonstrated prolonged overa...

    Authors: James Signorovitch, Elyse Swallow, Evan Kantor, Xufang Wang, Judith Klimovsky, Tomas Haas, Beth Devine and Peter Metrakos

    Citation: Experimental Hematology & Oncology 2013 2:32

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  27. Content type: Review

    Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatme...

    Authors: Theresa L Schwartz, Harveshp Mogal, Christos Papageorgiou, Jula Veerapong and Eddy C Hsueh

    Citation: Experimental Hematology & Oncology 2013 2:31

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  28. Content type: Review

    Neoadjuvant therapy is an under-utilized regimen for the treatment of metastatic melanoma. The use of this approach has been increasing in other tumor types. Neoadjuvant therapy may reduce occult circulating t...

    Authors: Shachar Laks, Kevin A Brueske and Eddy C Hsueh

    Citation: Experimental Hematology & Oncology 2013 2:30

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  29. Content type: Case report

    Mast cell activation syndrome (MCAS) is a relatively recently recognized cause of chronic multisystem polymorbidity of a generally inflammatory theme. Patients with MCAS often report migratory soft tissue and/...

    Authors: Lawrence B Afrin

    Citation: Experimental Hematology & Oncology 2013 2:28

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  30. Content type: Research

    In diffuse large B-cell lymphomas, gene expression profiling studies attributed a major biologic role to non-neoplastic cells of the tumour microenvironment as its composition and characteristics were shown to...

    Authors: Simone Brandt, Chiara Montagna, Antoin Georgis, Peter J Schüffler, Marco M Bühler, Burkhardt Seifert, Thore Thiesler, Alessandra Curioni-Fontecedro, Ivan Hegyi, Silvia Dehler, Vittoria Martin, Marianne Tinguely and Davide Soldini

    Citation: Experimental Hematology & Oncology 2013 2:27

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  31. Content type: Research

    Resistance to radiation treatment remains a major clinical problem for patients with brain cancer. Medulloblastoma is the most common malignant brain tumor of childhood, and occurs in the cerebellum. Though ra...

    Authors: Wendy J Ingram, Lisa M Crowther, Erica B Little, Ruth Freeman, Ivon Harliwong, Desi Veleva, Timothy E Hassall, Marc Remke, Michael D Taylor and Andrew R Hallahan

    Citation: Experimental Hematology & Oncology 2013 2:26

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  32. Content type: Short report

    Expression of the Epidermal Growth Factor Receptor ligand, Amphiregulin, has been associated with estrogen receptor positive breast cancer. As Amphiregulin is proteolytically released from the surface of breas...

    Authors: Esther A Peterson, Eirini Pectasides, Shabana Shabbeer, Lisa Wiechmann, Joseph A Sparano and Paraic A Kenny

    Citation: Experimental Hematology & Oncology 2013 2:25

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  33. Content type: Case report

    We present a case of a 42-year old female with the rare diagnosis of a myeloproliferative syndrome harboring both a BCR-ABL transclocation and a JAK2V617F mutation.

    Authors: Friederike Pastore, Stephanie Schneider, Oliver Christ, Wolfgang Hiddemann and Karsten Spiekermann

    Citation: Experimental Hematology & Oncology 2013 2:24

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  34. Content type: Research

    Opticin (OPTC) is a member of the small leucine-rich proteoglycan (SLRP) family and is localized particularly in certain extracellular matrices. We have previously reported the unique expression of another SLR...

    Authors: Eva Mikaelsson, Anders Österborg, Zahra Tahmasebi Fard, Ahmad Mahmoudi, Jafar Mahmoudian, Mahmood Jeddi-Tehrani, Mehdi Akhondi, Fazel Shokri, Paul N Bishop, Hodjattallah Rabbani and Håkan Mellstedt

    Citation: Experimental Hematology & Oncology 2013 2:23

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  35. Content type: Case report

    We report here on the diagnosis and successful treatment of a case of hairy cell leukemia (HCL) that arose 15 years after kidney transplantation in a 51-year-old patient. As soon as the diagnosis was made, HCL...

    Authors: Fabrizio Vinante, Paola Tomei, Gianluigi Zaza, Alberto Zamò and Antonio Lupo

    Citation: Experimental Hematology & Oncology 2013 2:22

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  36. Content type: Review

    Since low-molecular-weight heparins (LMWHs) are eliminated preferentially via the kidneys, the potential for accumulation of these agents (and an increased risk of bleeding) is of particular concern in populat...

    Authors: Kristian B Johansen and Torben Balchen

    Citation: Experimental Hematology & Oncology 2013 2:21

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  37. Content type: Research

    Primary adrenal lymphoma (PAL) is an extremely rare subtype of extranodal non-Hodgkin’s lymphoma. Some researchers have reported some of the characteristics of PAL and its association with poor prognosis; howe...

    Authors: Satoshi Ichikawa, Noriko Fukuhara, Ai Inoue, Hiroki Katsushima, Rie Ohba, Yuna Katsuoka, Yasushi Onishi, Joji Yamamoto, Osamu Sasaki, Jun Nomura, Osamu Fukuhara, Kenichi Ishizawa, Ryo Ichinohasama and Hideo Harigae

    Citation: Experimental Hematology & Oncology 2013 2:19

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  38. Content type: Research

    Oxythiamine (OT), an analogue of anti-metabolite, can suppress the nonoxidative synthesis of ribose and induce cell apoptosis by causing a G1 phase arrest in vitro and in vivo. However, the molecular mechanism re...

    Authors: Jiarui Wang, Xuemei Zhang, Danjun Ma, Wai-Nang Paul Lee, Jing Xiao, Yingchun Zhao, Vay Liang Go, Qi Wang, Yun Yen, Robert Recker and Gary Guishan Xiao

    Citation: Experimental Hematology & Oncology 2013 2:18

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  39. Content type: Review

    Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomark...

    Authors: Zhong Li

    Citation: Experimental Hematology & Oncology 2013 2:17

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  40. Content type: Research

    Tumor development is recently hypothesized to depend on a rare cell population with stem cell properties, such cells are called cancer stem cells (CSCs) or tumor-initiating cells (TICs). From various cancer ti...

    Authors: Ping Wang, Zhenhe Suo, Mengyu Wang, Hanne K Høifødt, Øystein Fodstad, Gustav Gaudernack and Gunnar Kvalheim

    Citation: Experimental Hematology & Oncology 2013 2:16

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  41. Content type: Review

    Tumor-associated antigens (TAAs) recognized by cellular and/or humoral effectors of the immune system are attractive targets for diagnostic and therapeutic approaches to human cancer. Different approaches can ...

    Authors: Liping Dai, Ningjing Lei, Mei Liu and Jian-Ying Zhang

    Citation: Experimental Hematology & Oncology 2013 2:15

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  42. Content type: Case report

    γδ T lymphocytes play an important role in immune reactions towards infections and malignancies. In particular, Vγ9Vδ1+ T lymphocytes are thought to play protective antiviral roles in human CMV infection. Recent...

    Authors: Immo Prinz, Kristina Thamm, Matthias Port, Eva M Weissinger, Michael Stadler, Ildar Gabaev, Roland Jacobs, Arnold Ganser and Christian Koenecke

    Citation: Experimental Hematology & Oncology 2013 2:14

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  43. Content type: Case report

    Cardiac metastasis of germ cell tumors is extremely rare, particularly in females. We report a case of a 26-year-old previously healthy woman who presented with a 5-month history of abdominal pain, weight loss...

    Authors: Maria Carmo Pereira Nunes, Daniel Ribeiro Moreira and Teresa Cristina Abreu Ferrari

    Citation: Experimental Hematology & Oncology 2013 2:13

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  44. Content type: Review

    Activation of plasminogen on the cell surface initiates a cascade of protease activity with important implications for several physiological and pathological events. In particular, components of the plasminoge...

    Authors: Patrizia Ceruti, Moitza Principe, Michela Capello, Paola Cappello and Francesco Novelli

    Citation: Experimental Hematology & Oncology 2013 2:12

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