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  1. In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy, as well as the leading cause of childhood cancer-related mortality. Advances in cyt...

    Authors: Jennifer S Woo, Michael O Alberti and Carlos A Tirado
    Citation: Experimental Hematology & Oncology 2014 3:16
    Content type: Review Published on:

  2. A 91-year-old woman affected with acquired Von Willebrand (VW) syndrome and intestinal angiodysplasias presented with severe gastrointestinal bleeding (hemoglobin 5 g/dl). Despite replacement therapy with VW f...

    Authors: Massimo Cugno, Alberto Tedeschi, Simona Maria Siboni, Francesca Stufano, Federica Depetri, Franca Franchi, Samantha Griffini and Flora Peyvandi
    Citation: Experimental Hematology & Oncology 2014 3:15
    Content type: Case report Published on:

  4. Recently, whole genome sequencing approaches have pinpointed mutations in genes that were previously not associated with cancer. For Acute Myeloid Leukaemia (AML), and other myeloid disorders, these approaches...

    Authors: Bryony Leeke, Judith Marsman, Justin M O’Sullivan and Julia A Horsfield
    Citation: Experimental Hematology & Oncology 2014 3:13
    Content type: Review Published on:

  5. Mesothelin, a mesothelial marker, has been found expressed in and as a potential treatment target of cholangioacarcinoma (CC). It is possible that CC may be derived from the cells sharing mesothelial markers. ...

    Authors: Lanjing Zhang, Renee Frank, Emma E Furth, Amy F Ziober, Virginia A LiVolsi and Paul J Zhang
    Citation: Experimental Hematology & Oncology 2014 3:12
    Content type: Research Published on:

  6. Recombinant human interleukin 12 (rHuIL-12) regulates hematopoiesis and cell-mediated immunity. Based on these hematopoietic and immunomodulatory activities, a recombinant human IL-12 (rHuIL-12) is now under d...

    Authors: Mamata S Gokhale, Vladimir Vainstein, Jamie Tom, Simmy Thomas, Chris E Lawrence, Zoya Gluzman-Poltorak, Nicholas Siebers and Lena A Basile
    Citation: Experimental Hematology & Oncology 2014 3:11
    Content type: Research Published on:

  7. This study examined patient outcomes using real world data for acute myeloid leukemia (AML) patients initiating treatment.

    Authors: B Douglas Smith, Charles L Beach, Dalia Mahmoud, Laura Weber and Henry J Henk
    Citation: Experimental Hematology & Oncology 2014 3:10
    Content type: Research Published on:

    The Erratum to this article has been published in Experimental Hematology & Oncology 2014 3:19

  8. Arsenic trioxide (ATO) is a novel form of therapy that has been found to aid acute promyelocytic leukemia (APL) patients. Our laboratory has demonstrated that ATO-induced cytotoxicity in human leukemia (HL-60)...

    Authors: Christian S Rogers, Clement G Yedjou, Dwayne J Sutton and Paul B Tchounwou
    Citation: Experimental Hematology & Oncology 2014 3:9
    Content type: Research Published on:

  9. The gene RUNX1 at chromosome 21q22 encodes the alpha subunit of Core binding factor (CBF), a heterodimeric transcription factor involved in the development of normal hematopoiesis. Translocations of RUNX1 are see...

    Authors: Jianling Ji, Eric Loo, Sheeja Pullarkat, Lynn Yang and Carlos A Tirado
    Citation: Experimental Hematology & Oncology 2014 3:8
    Content type: Case report Published on:

  10. Those stimuli that together promote the survival, differentiation and proliferation of the abnormal B-lymphocytes of chronic lymphocytic leukaemia (CLL) are encountered within tissues, where together they form...

    Authors: Claire V Hutchinson, Shiva Natarajan, Suzanne M Johnson, Julie A Adams, Karen S Rees-Unwin and John Burthem
    Citation: Experimental Hematology & Oncology 2014 3:7
    Content type: Research Published on:

  11. Here we report on a case of Philadelphia chromosome positive B lymphoblastic leukemia (Ph+ALL), which developed following a long duration of essential thrombocythemia (ET). A mutational analysis of Janus Kinase 2...

    Authors: Yuya Nagai, Masahiro Kawahara, Noriko Sugino, Yayoi Shimazu, Masakatsu Hishizawa, Kouhei Yamashita, Norimitsu Kadowaki and Akifumi Takaori-Kondo
    Citation: Experimental Hematology & Oncology 2014 3:6
    Content type: Case report Published on:

  12. Combination of phenethyl isothiocyanate (PEITC) and paclitaxel (taxol) has been shown to work synergistically to increase apoptosis and cell cycle arrest in breast cancer cells. In this report, we further expl...

    Authors: Shundong Cang, Yuehua Ma, Jen-wei Chiao and Delong Liu
    Citation: Experimental Hematology & Oncology 2014 3:5
    Content type: Research Published on:

  13. Research over the role of Bruton’s agammaglobulinemia tyrosine kinase (BTK) in B-lymphocyte development, differentiation, signaling and survival has led to better understanding of the pathogenesis of B-cell ma...

    Authors: Aileen Novero, Pavan M Ravella, Yamei Chen, George Dous and Delong Liu
    Citation: Experimental Hematology & Oncology 2014 3:4
    Content type: Review Published on:

  14. The host’s immune system is crucially involved in cancer development and progression. The ratio of regulatory to effector T-cells, as well as the interplay of T-cells with therapeutic agents, impact on cancer ...

    Authors: Anna Koumarianou, Maria-Ioanna Christodoulou, Pavlos Patapis, Iordanis Papadopoulos, Elissavet Liakata, Athina Giagini, Anastasia Stavropoulou, Nikiforita Poulakaki, Nikolaos Tountas, Nikolaos Xiros, Theophanis Economopoulos, Dimitris Pectasides, Ourania E Tsitsilonis and Vassiliki Pappa
    Citation: Experimental Hematology & Oncology 2014 3:3
    Content type: Research Published on:

  16. We analyze the epidemiological characteristics and outcomes of 72 patients diagnosed with non-metastatic inflammatory breast cancer (IBC) at National Institute of Oncology of Rabat in Morocco, between January ...

    Authors: Nabil Ismaili, Hind Elyaakoubi, Youssef Bensouda and Hassan Errihani
    Citation: Experimental Hematology & Oncology 2014 3:1
    Content type: Letter to the Editor Published on:

  17. The immune system is the built-in host defense mechanism against infectious agents as well as cancer. Protective immunity against cancer was convincingly demonstrated in the 1940s with syngeneic animal models ...

    Authors: Zihai Li, Lieping Chen and Mark P Rubinstein
    Citation: Experimental Hematology & Oncology 2013 2:33
    Content type: Review Published on:

  18. Everolimus and sunitinib have been approved for the treatment advanced pancreatic neuroendocrine tumors, but have not been compared to each other in a randomized trial and have not demonstrated prolonged overa...

    Authors: James Signorovitch, Elyse Swallow, Evan Kantor, Xufang Wang, Judith Klimovsky, Tomas Haas, Beth Devine and Peter Metrakos
    Citation: Experimental Hematology & Oncology 2013 2:32
    Content type: Research Published on:

  19. Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatme...

    Authors: Theresa L Schwartz, Harveshp Mogal, Christos Papageorgiou, Jula Veerapong and Eddy C Hsueh
    Citation: Experimental Hematology & Oncology 2013 2:31
    Content type: Review Published on:

  20. Neoadjuvant therapy is an under-utilized regimen for the treatment of metastatic melanoma. The use of this approach has been increasing in other tumor types. Neoadjuvant therapy may reduce occult circulating t...

    Authors: Shachar Laks, Kevin A Brueske and Eddy C Hsueh
    Citation: Experimental Hematology & Oncology 2013 2:30
    Content type: Review Published on:

  22. Mast cell activation syndrome (MCAS) is a relatively recently recognized cause of chronic multisystem polymorbidity of a generally inflammatory theme. Patients with MCAS often report migratory soft tissue and/...

    Authors: Lawrence B Afrin
    Citation: Experimental Hematology & Oncology 2013 2:28
    Content type: Case report Published on:

  23. In diffuse large B-cell lymphomas, gene expression profiling studies attributed a major biologic role to non-neoplastic cells of the tumour microenvironment as its composition and characteristics were shown to...

    Authors: Simone Brandt, Chiara Montagna, Antoin Georgis, Peter J Schüffler, Marco M Bühler, Burkhardt Seifert, Thore Thiesler, Alessandra Curioni-Fontecedro, Ivan Hegyi, Silvia Dehler, Vittoria Martin, Marianne Tinguely and Davide Soldini
    Citation: Experimental Hematology & Oncology 2013 2:27
    Content type: Research Published on:

  24. Resistance to radiation treatment remains a major clinical problem for patients with brain cancer. Medulloblastoma is the most common malignant brain tumor of childhood, and occurs in the cerebellum. Though ra...

    Authors: Wendy J Ingram, Lisa M Crowther, Erica B Little, Ruth Freeman, Ivon Harliwong, Desi Veleva, Timothy E Hassall, Marc Remke, Michael D Taylor and Andrew R Hallahan
    Citation: Experimental Hematology & Oncology 2013 2:26
    Content type: Research Published on:

  25. Expression of the Epidermal Growth Factor Receptor ligand, Amphiregulin, has been associated with estrogen receptor positive breast cancer. As Amphiregulin is proteolytically released from the surface of breas...

    Authors: Esther A Peterson, Eirini Pectasides, Shabana Shabbeer, Lisa Wiechmann, Joseph A Sparano and Paraic A Kenny
    Citation: Experimental Hematology & Oncology 2013 2:25
    Content type: Short report Published on:

  26. We present a case of a 42-year old female with the rare diagnosis of a myeloproliferative syndrome harboring both a BCR-ABL transclocation and a JAK2V617F mutation.

    Authors: Friederike Pastore, Stephanie Schneider, Oliver Christ, Wolfgang Hiddemann and Karsten Spiekermann
    Citation: Experimental Hematology & Oncology 2013 2:24
    Content type: Case report Published on:

  27. Opticin (OPTC) is a member of the small leucine-rich proteoglycan (SLRP) family and is localized particularly in certain extracellular matrices. We have previously reported the unique expression of another SLR...

    Authors: Eva Mikaelsson, Anders Österborg, Zahra Tahmasebi Fard, Ahmad Mahmoudi, Jafar Mahmoudian, Mahmood Jeddi-Tehrani, Mehdi Akhondi, Fazel Shokri, Paul N Bishop, Hodjattallah Rabbani and Håkan Mellstedt
    Citation: Experimental Hematology & Oncology 2013 2:23
    Content type: Research Published on:

  28. We report here on the diagnosis and successful treatment of a case of hairy cell leukemia (HCL) that arose 15 years after kidney transplantation in a 51-year-old patient. As soon as the diagnosis was made, HCL...

    Authors: Fabrizio Vinante, Paola Tomei, Gianluigi Zaza, Alberto Zamò and Antonio Lupo
    Citation: Experimental Hematology & Oncology 2013 2:22
    Content type: Case report Published on:

  29. Since low-molecular-weight heparins (LMWHs) are eliminated preferentially via the kidneys, the potential for accumulation of these agents (and an increased risk of bleeding) is of particular concern in populat...

    Authors: Kristian B Johansen and Torben Balchen
    Citation: Experimental Hematology & Oncology 2013 2:21
    Content type: Review Published on:

  31. Primary adrenal lymphoma (PAL) is an extremely rare subtype of extranodal non-Hodgkin’s lymphoma. Some researchers have reported some of the characteristics of PAL and its association with poor prognosis; howe...

    Authors: Satoshi Ichikawa, Noriko Fukuhara, Ai Inoue, Hiroki Katsushima, Rie Ohba, Yuna Katsuoka, Yasushi Onishi, Joji Yamamoto, Osamu Sasaki, Jun Nomura, Osamu Fukuhara, Kenichi Ishizawa, Ryo Ichinohasama and Hideo Harigae
    Citation: Experimental Hematology & Oncology 2013 2:19
    Content type: Research Published on:

  32. Oxythiamine (OT), an analogue of anti-metabolite, can suppress the nonoxidative synthesis of ribose and induce cell apoptosis by causing a G1 phase arrest in vitro and in vivo. However, the molecular mechanism re...

    Authors: Jiarui Wang, Xuemei Zhang, Danjun Ma, Wai-Nang Paul Lee, Jing Xiao, Yingchun Zhao, Vay Liang Go, Qi Wang, Yun Yen, Robert Recker and Gary Guishan Xiao
    Citation: Experimental Hematology & Oncology 2013 2:18
    Content type: Research Published on:

  33. Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomark...

    Authors: Zhong Li
    Citation: Experimental Hematology & Oncology 2013 2:17
    Content type: Review Published on:

  34. Tumor development is recently hypothesized to depend on a rare cell population with stem cell properties, such cells are called cancer stem cells (CSCs) or tumor-initiating cells (TICs). From various cancer ti...

    Authors: Ping Wang, Zhenhe Suo, Mengyu Wang, Hanne K Høifødt, Øystein Fodstad, Gustav Gaudernack and Gunnar Kvalheim
    Citation: Experimental Hematology & Oncology 2013 2:16
    Content type: Research Published on:

  35. Tumor-associated antigens (TAAs) recognized by cellular and/or humoral effectors of the immune system are attractive targets for diagnostic and therapeutic approaches to human cancer. Different approaches can ...

    Authors: Liping Dai, Ningjing Lei, Mei Liu and Jian-Ying Zhang
    Citation: Experimental Hematology & Oncology 2013 2:15
    Content type: Review Published on:

  36. γδ T lymphocytes play an important role in immune reactions towards infections and malignancies. In particular, Vγ9–Vδ1+ T lymphocytes are thought to play protective antiviral roles in human CMV infection. Recent...

    Authors: Immo Prinz, Kristina Thamm, Matthias Port, Eva M Weissinger, Michael Stadler, Ildar Gabaev, Roland Jacobs, Arnold Ganser and Christian Koenecke
    Citation: Experimental Hematology & Oncology 2013 2:14
    Content type: Case report Published on:

  37. Cardiac metastasis of germ cell tumors is extremely rare, particularly in females. We report a case of a 26-year-old previously healthy woman who presented with a 5-month history of abdominal pain, weight loss...

    Authors: Maria Carmo Pereira Nunes, Daniel Ribeiro Moreira and Teresa Cristina Abreu Ferrari
    Citation: Experimental Hematology & Oncology 2013 2:13
    Content type: Case report Published on:

  38. Activation of plasminogen on the cell surface initiates a cascade of protease activity with important implications for several physiological and pathological events. In particular, components of the plasminoge...

    Authors: Patrizia Ceruti, Moitza Principe, Michela Capello, Paola Cappello and Francesco Novelli
    Citation: Experimental Hematology & Oncology 2013 2:12
    Content type: Review Published on:

  40. CD56 expression has been associated with a poor prognosis in lymphoid neoplasms, including T-cell acute lymphoblastic leukemia (T-ALL). MicroRNAs (miRNAs) play an important role in lymphoid differentiation, an...

    Authors: Hamilton L Gimenes-Teixeira, Antonio R Lucena-Araujo, Guilherme A dos Santos, Dalila L Zanette, Priscila S Scheucher, Luciana C Oliveira, Leandro F Dalmazzo, Wilson A Silva-Júnior, Roberto P Falcão and Eduardo M Rego
    Citation: Experimental Hematology & Oncology 2013 2:10
    Content type: Research Published on:

  41. Less is known about the non-mesenchymal mononuclear cell fraction of human bone marrow on functional adaptation of neuroblastoma cells. Using immunocytochemistry, we showed that bone-marrow mononuclear cell (B...

    Authors: Chareerut Phruksaniyom, Permphan Dharmasaroja and Surapol Issaragrisil
    Citation: Experimental Hematology & Oncology 2013 2:9
    Content type: Letter to the Editor Published on:

  42. Among the dendritic cell (DC) subsets, plasmacytoid DC’s (pDC) are thought to be important in the generation of both antiviral and antitumor responses. While pDC may be useful in developing dendritic cell-base...

    Authors: Stephen H Wrzesinski, Jan L Fisher and Marc S Ernstoff
    Citation: Experimental Hematology & Oncology 2013 2:8
    Content type: Rapid communication Published on:

  43. High levels of BAALC, ERG, EVI1 and MN1 expression have been associated with shorter overall survival in AML but standardized and clinically validated assays are lacking. We have therefore developed and optimized...

    Authors: Jaap Brand, Martin H van Vliet, Leonie de Best, Peter JM Valk, Henk E Viëtor, Bob Löwenberg and Erik H van Beers
    Citation: Experimental Hematology & Oncology 2013 2:7
    Content type: Research Published on:

  45. Dasatinib 100 mg daily and nilotinib 600/800 mg daily have been compared to imatinib as first line treatments for CML in two recent randomised studies. However, no head to head evidence exists of the relative ...

    Authors: Stuart Mealing, Leticia Barcena, Neil Hawkins, James Clark, Victoria Eaton, Ishan Hirji and Catherine Davis
    Citation: Experimental Hematology & Oncology 2013 2:5
    Content type: Research Published on:

  46. We previously showed that B-cell receptor (BCR) signaling pathways are important for in vitro survival of mantle cell lymphoma (MCL) cells. To further identify early BCR-activated signaling pathways involved in M...

    Authors: Mohand-Akli Boukhiar, Claudine Roger, Julie Tran, Remy Gressin, Antoine Martin, Florence Ajchenbaum-Cymbalista, Nadine Varin-Blank, Dominique Ledoux and Fanny Baran-Marszak
    Citation: Experimental Hematology & Oncology 2013 2:4
    Content type: Research Published on:

  47. Platelet function disorders (PFDs) have emerged as an important etiology of heavy menstrual bleeding (HMB) in adolescents. However, neither clinical nor laboratory data have been methodically analyzed in this ...

    Authors: Lawrence S Amesse, Teresa Pfaff-Amesse, William T Gunning, Nancy Duffy and James A French II
    Citation: Experimental Hematology & Oncology 2013 2:3
    Content type: Research Published on:

  48. In clinical and experimental settings, antibody-based anti-CD20/rituximab and small molecule proteasome inhibitor (PI) bortezomib (BTZ) treatment proved effective modalities for B cell depletion in lymphoproli...

    Authors: Sue Ellen Verbrugge, Marjon Al, Yehuda G Assaraf, Denise Niewerth, Johan van Meerloo, Jacqueline Cloos, Michael van der Veer, George L Scheffer, Godefridus J Peters, Elena T Chan, Janet L Anderl, Christopher J Kirk, Sonja Zweegman, Ben AC Dijkmans, Willem F Lems, Rik J Scheper…
    Citation: Experimental Hematology & Oncology 2013 2:2
    Content type: Research Published on:

  49. T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare subtype of diffuse large B-cell lymphoma, and has been reported to mainly affect lymph nodes with advanced Ann Arbor stage. We present a 69-year...

    Authors: Satoshi Ichikawa, Yasuaki Watanabe, Kei Saito, Jun Kimura, Ryo Ichinohasama and Hideo Harigae
    Citation: Experimental Hematology & Oncology 2013 2:1
    Content type: Letter to the Editor Published on:

  50. Polo-like kinase 1 (Plk1) is an interesting molecule both as a biomarker and as a target for highly specific cancer therapy for several reasons. Firstly, it is over-expressed in many cancers and can serve as a...

    Authors: Lily Weiß and Thomas Efferth
    Citation: Experimental Hematology & Oncology 2012 1:38
    Content type: Review Published on:
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