Articles

Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse

This report describes the clinical courses of two acute myeloid leukemia patients. Both had MLL translocations, the first a t(10;11)(p11.2;q23) with MLL-AF10 and the second a t(11;19)(q23;p13.1) with MLL-ELL fusi...

Authors: Thomas Burmeister, Mara Molkentin, Claus Meyer, Nils Lachmann, Stefan Schwartz, Birte Friedrichs, Jörg Beyer, Igor Wolfgang Blau, Gunnar Lohm, Carola Tietze-Bürger, Rolf Marschalek and Lutz Uharek

Digitoxin and its analogs as novel cancer therapeutics

A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinica...

Authors: Hosam A Elbaz, Todd A Stueckle, William Tse, Yon Rojanasakul and Cerasela Zoica Dinu

Large granular lymphocytosis with severe neutropenia following ipilimumab therapy for metastatic melanoma

Authors: Guoqing Wei, Uzoma Nwakuche, Gustavo Cadavid, Asim Ajaz, Karen Seiter and Delong Liu

Oxidative stress and redox state-regulating enzymes have prognostic relevance in diffuse large B-cell lymphoma

Oxidative stress and redox-regulating enzymes may have roles both in lymphomagenesis and resistance to lymphoma therapy. Previous studies from the pre-rituximab era suggest that antioxidant enzyme expression i...

Authors: Pekka Peroja, Anna Kaisa Pasanen, Kirsi-Maria Haapasaari, Esa Jantunen, Ylermi Soini, Taina Turpeenniemi-Hujanen, Risto Bloigu, Laura Lilja, Outi Kuittinen and Peeter Karihtala

Publish, not perish: Introducing Experimental Hematology & Oncology

As a scientific discipline, medicine can only be advanced by experimentation. Experimentation could either validate or refute a hypothesis. Unfortunately, today's publication climate strongly favors publicatio...

Authors: Zihai Li, Chung-Tsen Hsueh and Delong Liu