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  1. Content type: Research

    Oxythiamine (OT), an analogue of anti-metabolite, can suppress the nonoxidative synthesis of ribose and induce cell apoptosis by causing a G1 phase arrest in vitro and in vivo. However, the molecular mechanism re...

    Authors: Jiarui Wang, Xuemei Zhang, Danjun Ma, Wai-Nang Paul Lee, Jing Xiao, Yingchun Zhao, Vay Liang Go, Qi Wang, Yun Yen, Robert Recker and Gary Guishan Xiao

    Citation: Experimental Hematology & Oncology 2013 2:18

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  2. Content type: Review

    Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomark...

    Authors: Zhong Li

    Citation: Experimental Hematology & Oncology 2013 2:17

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  3. Content type: Research

    Tumor development is recently hypothesized to depend on a rare cell population with stem cell properties, such cells are called cancer stem cells (CSCs) or tumor-initiating cells (TICs). From various cancer ti...

    Authors: Ping Wang, Zhenhe Suo, Mengyu Wang, Hanne K Høifødt, Øystein Fodstad, Gustav Gaudernack and Gunnar Kvalheim

    Citation: Experimental Hematology & Oncology 2013 2:16

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  4. Content type: Review

    Tumor-associated antigens (TAAs) recognized by cellular and/or humoral effectors of the immune system are attractive targets for diagnostic and therapeutic approaches to human cancer. Different approaches can ...

    Authors: Liping Dai, Ningjing Lei, Mei Liu and Jian-Ying Zhang

    Citation: Experimental Hematology & Oncology 2013 2:15

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  5. Content type: Case report

    γδ T lymphocytes play an important role in immune reactions towards infections and malignancies. In particular, Vγ9Vδ1+ T lymphocytes are thought to play protective antiviral roles in human CMV infection. Recent...

    Authors: Immo Prinz, Kristina Thamm, Matthias Port, Eva M Weissinger, Michael Stadler, Ildar Gabaev, Roland Jacobs, Arnold Ganser and Christian Koenecke

    Citation: Experimental Hematology & Oncology 2013 2:14

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  6. Content type: Case report

    Cardiac metastasis of germ cell tumors is extremely rare, particularly in females. We report a case of a 26-year-old previously healthy woman who presented with a 5-month history of abdominal pain, weight loss...

    Authors: Maria Carmo Pereira Nunes, Daniel Ribeiro Moreira and Teresa Cristina Abreu Ferrari

    Citation: Experimental Hematology & Oncology 2013 2:13

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  7. Content type: Review

    Activation of plasminogen on the cell surface initiates a cascade of protease activity with important implications for several physiological and pathological events. In particular, components of the plasminoge...

    Authors: Patrizia Ceruti, Moitza Principe, Michela Capello, Paola Cappello and Francesco Novelli

    Citation: Experimental Hematology & Oncology 2013 2:12

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  8. Content type: Research

    CD56 expression has been associated with a poor prognosis in lymphoid neoplasms, including T-cell acute lymphoblastic leukemia (T-ALL). MicroRNAs (miRNAs) play an important role in lymphoid differentiation, an...

    Authors: Hamilton L Gimenes-Teixeira, Antonio R Lucena-Araujo, Guilherme A dos Santos, Dalila L Zanette, Priscila S Scheucher, Luciana C Oliveira, Leandro F Dalmazzo, Wilson A Silva-Júnior, Roberto P Falcão and Eduardo M Rego

    Citation: Experimental Hematology & Oncology 2013 2:10

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  9. Content type: Letter to the Editor

    Less is known about the non-mesenchymal mononuclear cell fraction of human bone marrow on functional adaptation of neuroblastoma cells. Using immunocytochemistry, we showed that bone-marrow mononuclear cell (B...

    Authors: Chareerut Phruksaniyom, Permphan Dharmasaroja and Surapol Issaragrisil

    Citation: Experimental Hematology & Oncology 2013 2:9

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  10. Content type: Rapid communication

    Among the dendritic cell (DC) subsets, plasmacytoid DC’s (pDC) are thought to be important in the generation of both antiviral and antitumor responses. While pDC may be useful in developing dendritic cell-base...

    Authors: Stephen H Wrzesinski, Jan L Fisher and Marc S Ernstoff

    Citation: Experimental Hematology & Oncology 2013 2:8

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  11. Content type: Research

    High levels of BAALC, ERG, EVI1 and MN1 expression have been associated with shorter overall survival in AML but standardized and clinically validated assays are lacking. We have therefore developed and optimized...

    Authors: Jaap Brand, Martin H van Vliet, Leonie de Best, Peter JM Valk, Henk E Viëtor, Bob Löwenberg and Erik H van Beers

    Citation: Experimental Hematology & Oncology 2013 2:7

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  12. Content type: Research

    Dasatinib 100 mg daily and nilotinib 600/800 mg daily have been compared to imatinib as first line treatments for CML in two recent randomised studies. However, no head to head evidence exists of the relative ...

    Authors: Stuart Mealing, Leticia Barcena, Neil Hawkins, James Clark, Victoria Eaton, Ishan Hirji and Catherine Davis

    Citation: Experimental Hematology & Oncology 2013 2:5

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  13. Content type: Research

    We previously showed that B-cell receptor (BCR) signaling pathways are important for in vitro survival of mantle cell lymphoma (MCL) cells. To further identify early BCR-activated signaling pathways involved in M...

    Authors: Mohand-Akli Boukhiar, Claudine Roger, Julie Tran, Remy Gressin, Antoine Martin, Florence Ajchenbaum-Cymbalista, Nadine Varin-Blank, Dominique Ledoux and Fanny Baran-Marszak

    Citation: Experimental Hematology & Oncology 2013 2:4

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  14. Content type: Research

    Platelet function disorders (PFDs) have emerged as an important etiology of heavy menstrual bleeding (HMB) in adolescents. However, neither clinical nor laboratory data have been methodically analyzed in this ...

    Authors: Lawrence S Amesse, Teresa Pfaff-Amesse, William T Gunning, Nancy Duffy and James A French II

    Citation: Experimental Hematology & Oncology 2013 2:3

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  15. Content type: Research

    In clinical and experimental settings, antibody-based anti-CD20/rituximab and small molecule proteasome inhibitor (PI) bortezomib (BTZ) treatment proved effective modalities for B cell depletion in lymphoproli...

    Authors: Sue Ellen Verbrugge, Marjon Al, Yehuda G Assaraf, Denise Niewerth, Johan van Meerloo, Jacqueline Cloos, Michael van der Veer, George L Scheffer, Godefridus J Peters, Elena T Chan, Janet L Anderl, Christopher J Kirk, Sonja Zweegman, Ben AC Dijkmans, Willem F Lems, Rik J Scheper…

    Citation: Experimental Hematology & Oncology 2013 2:2

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  16. Content type: Letter to the Editor

    T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare subtype of diffuse large B-cell lymphoma, and has been reported to mainly affect lymph nodes with advanced Ann Arbor stage. We present a 69-year...

    Authors: Satoshi Ichikawa, Yasuaki Watanabe, Kei Saito, Jun Kimura, Ryo Ichinohasama and Hideo Harigae

    Citation: Experimental Hematology & Oncology 2013 2:1

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  17. Content type: Research

    Clofarabine alone or in combination with cyclophosphamide and etoposide has shown a good efficacy and a tolerable toxicity profile in previous studies of children with relapsed or refractory leukaemia. This re...

    Authors: Pascale Trioche, Brigitte Nelken, Gérard Michel, Isabelle Pellier, Arnaud Petit, Yves Bertrand, Pierre Rohrlich, Claudine Schmitt, Nicolas Sirvent, Patrick Boutard, Geneviève Margueritte, Brigitte Pautard, Stéphane Ducassou, Dominique Plantaz, Alain Robert, Caroline Thomas…

    Citation: Experimental Hematology & Oncology 2012 1:39

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  18. Content type: Review

    Polo-like kinase 1 (Plk1) is an interesting molecule both as a biomarker and as a target for highly specific cancer therapy for several reasons. Firstly, it is over-expressed in many cancers and can serve as a...

    Authors: Lily Weiß and Thomas Efferth

    Citation: Experimental Hematology & Oncology 2012 1:38

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  19. Content type: Case report

    Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of...

    Authors: Sied Kebir, Klaus Kuchelmeister, Pitt Niehusmann, Michael Nelles, Young Kim, Sharmilan Thanendrarajan, Niklas Schäfer, Moritz Stuplich, Frederic Mack, Björn Scheffler, Horst Urbach, Martin Glas and Ulrich Herrlinger

    Citation: Experimental Hematology & Oncology 2012 1:37

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  20. Content type: Short report

    Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression...

    Authors: Erika Elgström, Sophie E Eriksson, Tomas G Ohlsson, Jan Tennvall and Rune Nilsson

    Citation: Experimental Hematology & Oncology 2012 1:34

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  21. Content type: Research

    The amplification of putative oncogenes is a common finding within the genome of various cancer types. Identification and further targeting of specific junction sites within the sequence of genomic amplicons (...

    Authors: Axel Weber, Sylvia Taube, Udo zur Stadt, Martin Horstmann, Knut Krohn, Jutta Bradtke, Andrea Teigler-Schlegel, Sabine Leiblein and Holger Christiansen

    Citation: Experimental Hematology & Oncology 2012 1:33

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  22. Content type: Case report

    Therapy of indolent lymphomas with involvement of the central nervous system (CNS) has not been standardized so far. A 42-year old male patient presented with neurological signs because of leukemic splenic mar...

    Authors: Christoph Busemann, Andrej Gudzuhn, Carsten Hirt, Michael Kirsch, Silke Vogelgesang, Christian A Schmidt, Gottfried Dölken and William H Krüger

    Citation: Experimental Hematology & Oncology 2012 1:32

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  23. Content type: Case report

    Radiation therapy (RT) after breast conservation therapy has recently been linked with significant reduction in risk of ipsilateral breast cancer among BRCA1 mutation carriers. However, the exact mechanism by whi...

    Authors: Huai-Chin Chiang, Sreejith J Nair, I-Tien Yeh, Alfredo A Santillan, Yanfen Hu, Richard Elledge and Rong Li

    Citation: Experimental Hematology & Oncology 2012 1:31

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  24. Content type: Short report

    The treatment strategy for gastric diffuse large cell lymphoma (DLBCL) has not been standardized in such as to the cycles of chemotherapy, dose of radiation, or necessity for the surgery. Although the results ...

    Authors: Yuko Mishima, Yasuhito Terui, Masahiro Yokoyama, Noriko Nishimura, Sakura Sakajiri, Kyoko Ueda, Yasutoshi Kuboki, Kenji Nakano, Kazuhito Suzuki, Eriko Nara, Naoko Tsuyama, Kengo Takeuchi, Masahiko Oguchi and Kiyohiko Hatake

    Citation: Experimental Hematology & Oncology 2012 1:30

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  25. Content type: Case report

    We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after allogeneic hema...

    Authors: Paul Farnsworth, David Ward and Vijay Reddy

    Citation: Experimental Hematology & Oncology 2012 1:29

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  26. Content type: Case report

    Chronic lymphocytic leukemia (CLL) rarely exhibits an aggressive clinical course and its patients often have chromosomal deletions or additions. Furthermore, reciprocal translocations are barely observed in CL...

    Authors: Kayo Harada, Kazuhiko Ikeda, Hayato Matsumoto, Miki Furukawa, Hiroshi Takahashi, Hiroshi Ohkawara, Hideyoshi Noji, Kazuhiro Tasaki, Masafumi Abe, Kazuei Ogawa and Yasuchika Takeishi

    Citation: Experimental Hematology & Oncology 2012 1:28

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  27. Content type: Review

    Multiple myeloma is an incurable malignant disorder of mature B-cells that predominantly affects the elderly. The immunomodulatory drug (IMiD) thalidomide and its newer analogs demonstrate increased antitumor ...

    Authors: Tahir Latif, Nabeel Chauhan, Rashid Khan, Andrea Moran and Saad Z Usmani

    Citation: Experimental Hematology & Oncology 2012 1:27

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  28. Content type: Case report

    Paroxysmal nocturnal hemoglobinuria (PNH) is a progressive, life-threatening disorder characterized by chronic intravascular hemolysis caused by uncontrolled complement activation. Hepatic vein thrombosis (Bud...

    Authors: Andrés Brodsky, Octavio Mazzocchi, Fabiana Sánchez, Gus Khursigara, Suneil Malhotra and Mariano Volpacchio

    Citation: Experimental Hematology & Oncology 2012 1:26

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  29. Content type: Rapid communication

    Inhibitors of apoptosis (IAPs) were intensively investigated in the context of cancer where they promote tumor growth and chemoresistence. Overexpression of the IAP BIRC6 is associated with unfavorable clinical f...

    Authors: Anna M Schläfli, Bruce E Torbett, Martin F Fey and Mario P Tschan

    Citation: Experimental Hematology & Oncology 2012 1:25

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  30. Content type: Case report

    Extreme swing of phosphor from severe hyperphosphatemia to severe hypophosphatemia in a patient with blast crisis of myeloid origin was the result of imbalance between massive apoptosis of leukemic cells in th...

    Authors: Ophira Salomon, Eli J Holtzman, Pazit Beckerman, Camila Avivi, Luba Trakhtenbrot, Abraham Kneller, Tali Tohami, Yeroham Kleinbaum, Sara Apter, Ninette Amariglio, Ehud Grossman and Ginette Schiby

    Citation: Experimental Hematology & Oncology 2012 1:24

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  31. Content type: Short report

    The computational fluid dynamics method, which provides an estimation of the pressure drop in the airway before and after the stent implantation, is proposed in this study. This method is based on the finite v...

    Authors: Chien-Yi Ho, Hsiu-Mei Liao, Chih-Yen Tu, Chih-Yang Huang, Chuen-Ming Shih, Min-Ying Lydia Su, Jeon-Hor Chen and Tzu-Ching Shih

    Citation: Experimental Hematology & Oncology 2012 1:23

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  32. Content type: Review

    The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene altera...

    Authors: Xin Huang, Xin Du and Yangqiu Li

    Citation: Experimental Hematology & Oncology 2012 1:22

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  33. Content type: Case report

    T-cell prolymphocytic leukemia (T-PLL) is a rare form of leukemia composed of mature T-cells that usually presents in older people with a median age of 65. Most cases of T-PLL will harbor chromosomal abnormali...

    Authors: Carlos A Tirado, Phillip Starshak, Paul Delgado and Nagesh Rao

    Citation: Experimental Hematology & Oncology 2012 1:21

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  34. Content type: Case report

    Two major types of amyloidosis are primary amyloidosis or amyloid light chain amyloidosis and secondary amyloidosis. Although amyloidosis involves a variety of organ systems including skin, the occurrence of b...

    Authors: Aref Agheli, Marvin Becker, Gary Becker, M Rashid Chaudhry and Jen C Wang

    Citation: Experimental Hematology & Oncology 2012 1:19

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  35. Content type: Research

    The transcription factor E2F1 has been implicated in cell cycle control and DNA damage response. Paradoxically, E2F1 can promote apoptosis and function as tumor suppressor. In non-small cell lung cancer (NSCLC...

    Authors: Jung-Jyh Hung, Chung-Tsen Hsueh, Kuan-Hua Chen, Wen-Hu Hsu and Yu-Chung Wu

    Citation: Experimental Hematology & Oncology 2012 1:18

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  36. Content type: Letter to the Editor

    Tyrosine kinase inhibitors specific for BCR-ABL, were a major breakthrough in CML therapy. Second generation tyrosine kinase inhibitors (dasatinib, nilotinib) are indicated for imatinib resistant and intoleran...

    Authors: Klára Gadó, András Matolcsy, Judit Csomor, Dóra Kicsi, Csaba Bödör and Gyula Domján

    Citation: Experimental Hematology & Oncology 2012 1:17

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  37. Content type: Case report

    A 57-year-old male with a history of hypertension presented with shortness of breath, intermittent substernal chest pain, subjective fevers, and a 30-pound weight loss. He was found to have a bladder mass four...

    Authors: Joshua R Peck, Charles L Hitchcock, Sara Maguire, Jennifer Dickerson and Charles Bush

    Citation: Experimental Hematology & Oncology 2012 1:16

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  38. Content type: Rapid communication

    JAK2V617F, a gain-of-function mutant form of tyrosine kinase JAK2, is found in the majority of patients with Ph- myeloproliferative neoplasms (MPNs), a group of chronic hematological diseases that often lead t...

    Authors: Wanke Zhao, Yanhong Du, Wanting Tina Ho, Xueqi Fu and Zhizhuang Joe Zhao

    Citation: Experimental Hematology & Oncology 2012 1:15

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  39. Content type: Review

    Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI) tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years....

    Authors: Gurpreet Lamba, Ridhi Gupta, Byung Lee, Samir Ambrale and Delong Liu

    Citation: Experimental Hematology & Oncology 2012 1:14

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  40. Content type: Short report

    We present our initial experience of allogeneic stem cell transplant procedure performed between April 2004 and August 2011 for various haematological disorders. All patients with non-malignant and malignant h...

    Authors: Natasha Ali, Salman Naseem Adil, Mohammad Usman Shaikh, Munira Moosajee and Nehal Masood

    Citation: Experimental Hematology & Oncology 2012 1:13

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  41. Content type: Review

    Hematopoietic stem cells (HSCs) are rare cells that have the unique ability to self-renew and differentiate into cells of all hematopoietic lineages. The expansion of HSCs has remained an important goal to dev...

    Authors: Jessica A Schuster, Maria R Stupnikov, Gina Ma, Wenbin Liao, Raymond Lai, Yupo Ma and Jerell R Aguila

    Citation: Experimental Hematology & Oncology 2012 1:12

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  42. Content type: Research

    Liposomal formulations of anthracyclines appear to have favorable toxicity profile when compared with conventional anthracyclines in elderly, high risk cardiac patients and patients with prior use of anthracyc...

    Authors: Shamudheen M Rafiyath, Mohammad Rasul, Byung Lee, Guoqing Wei, Gurpreet Lamba and Delong Liu

    Citation: Experimental Hematology & Oncology 2012 1:10

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  43. Content type: Research

    HevyLite™ is a new, recently developed method that facilitates separate quantification of the kappa- and lambda-bounded amounts of a given immunoglobulin (Ig). Using this method, we measured intact immunoglobu...

    Authors: Efstathios Koulieris, Panayiotis Panayiotidis, Stephen J Harding, Nikolitsa Kafasi, Dimitris Maltezas, Vassiliki Bartzis, Tatiana Tzenou, Maria Dimou, George Georgiou, Ladan Mirbahai, Arthur R Bradwell and Marie-Christine Kyrtsonis

    Citation: Experimental Hematology & Oncology 2012 1:9

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  44. Content type: Case report

    A patient with acute lymphoblastic leukemia repeatedly developed hypoglycemia during chemotherapy. Comparison of serum glucose trends between chemotherapy with and without L-asparaginase (L-Asp) demonstrated a...

    Authors: Ryuma Tanaka, Tomoo Osumi, Masashi Miharu, Tomohiro Ishii, Tomonobu Hasegawa, Takao Takahashi and Hiroyuki Shimada

    Citation: Experimental Hematology & Oncology 2012 1:8

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