Fig. 1

Changes in Bi-dimensional tumor measurements of target and non-target lesions. Computer tomography (CT) scans depict imaging studies done on 5/13/2015 (above) and 7/15/2015 (middle). Lower graph depicts changes in size of target and non-target lesions at both time-points. Tumors were evaluated using Response Evaluation Criteria In Solid Tumors (RECIST v1.1). Left axis depicts maximal bi-dimensional measurement for 4 (1 target and 3 non-target) lesions while right axis depicts sum of maximal bi-dimensional measurements for all 4 lesions. All measurements are in mm. Nivolumab 3 mg/kg was administered on 5/20/2015 but subsequent doses were missed given multiple admissions. Prior to resumption of therapy following multiple admissions, a restaging scan was repeated on 7/15/2015. Remarkably, all lesions had shrunk considerably with 2 non-target lesions (left pleural nodule and para esophageal lymph node) disappearing completely after a single dose of nivolumab. Patient received 3 doses of nivolumab between 7/8/2015 and 8/12/2015. Therapy is ongoing with continued response