Figure 1From: Current management and prognostic features for gastrointestinal stromal tumor (GIST) The structure of KIT/CD117 and the signal transduction. KIT is a transmembrane receptor type tyrosine knase. The stem cell factor/KIT ligand binds to KIT and activates the KIT tyrosine kinase. The phosphorylated (activated) KIT then activates its substrates which lead to cell proliferation.Back to article page