Fig. 8

Regulatory networks and corresponding therapeutic interventions targeting PD-1/PD-L1 posttranslational modifications. The figure illustrates various therapies targeting PD-L1 and PD-1 post-translational modifications. The colored regions—purple, red, blue, green, brown, pink, gray, orange, and yellow—correspond sequentially to deubiquitination, glycosylation, ectodomain shedding, acetylation, UFMylation, phosphorylation, ubiquitination, autophagy degradation, and S-palmitoylation modifications. Adjacent to each colored region, the outer grids display the related molecules and potential therapeutic drugs targeting these specific post-translational modifications