Table 3 The agent-specific reported adverse effects associated with HDACis
HDACi | Specific adverse effects reported in clinical trials |
|---|---|
Panobinostat | Cardiac ischaemia, haemorrhage |
Vorinostat | Hyper-glycaemia, pulmonary embolism, deep vein thrombosis |
Belinostat | Infections, tumour lysis syndrome |
Romidepsin | Infections, tumour lysis syndrome |
Chidamide | Raised creatine phosphokinase levels, pericardial effusion |