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Fig. 6 | Experimental Hematology & Oncology

Fig. 6

From: Exploring the role of histone deacetylase and histone deacetylase inhibitors in the context of multiple myeloma: mechanisms, therapeutic implications, and future perspectives

Fig. 6

Mechanistic illustration of HDAC6 in STAT3-PD-L1 pathway: When HDAC6 levels are high, STAT3 accumulates in a phosphorylated form, reducing the interaction between STAT3 and PP2A. After entering the nucleus, pSTAT3 and HDAC6 bind to the PD-L1 promoter, promoting PD-L1 expression. Figure created with BioRender.com

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Experimental Hematology & Oncology

ISSN: 2162-3619

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