Fig. 4
From: Enhanced cellular therapy: revolutionizing adoptive cellular therapy
Roles of specific cytokines in ACT. IL-2 and IL-15 can trigger the secretion of granzymes, perforin, IL-2, IFN- γ, and TNF- α by CAR-T cells, promoting the apoptosis of tumor cells. IL-1β can promote the expansion of effector T cells and CAR-T cells. IFN- γ enhances the expression and persistence of IFN- γ, which can recruit white blood cells to stimulate lasting immunity, activate the macrophage, and increase the expression of MHC on APC