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Fig. 6 | Experimental Hematology & Oncology

Fig. 6

From: GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment

Fig. 6

Loss of GPR68 causes ferroptosis in GBM. (A) OGM decreased GSH levels in U87 cells. (B, C) OGM significantly increased lipid peroxidation in U87 and U138. Chi square T(X) > 4 is considered significant. (D) OGM disrupted Mitochondria structure (Mitotracker) and function (TMRM) in U87, but not lysosome structure (Lysotracker). (E) Quantification of TMRM in U87 and U138. (F) Ultrastructure of U87 cells treated with OGM show disrupted mitochondria: *, but normal ER (arrowhead)

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Experimental Hematology & Oncology

ISSN: 2162-3619

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