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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment

Fig. 5

OGM causes ferroptosis in PDX models of GBM. (A) Known markers and mediators of ferroptosis were increased in PDX cells treated with OGM. (B) Known suppressors of ferroptosis were decreased in PDX cells treated with OGM. (C) ATF4 and CHAC1, involved in both ferroptosis and ER stress response, were increased in OGM treatment groups. (D) OGM and Erastin demonstrated very strong for induction of lipid peroxidation in Mayo6 cells. All treatments were highly significant with Chi-squared > 4, which is equal to p < 0.01) (E) At the concentrations used OGM and Erastin both caused significant cell death (F) OGM and Erastin demonstrated very strong induction of lipid peroxidation in Mayo39 cells. All treatments were highly significant with Chi-squared > 4, which is equal to p < 0.01) (G) At the concentrations used OGM and Erastin both caused significant cell death (H) OGM induced key markers of ferroptosis ATF4, CHAC1, HMOX1, TFRC, and SLC7A11, confirmed via qPCR in PDX lines

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Experimental Hematology & Oncology

ISSN: 2162-3619

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