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Fig. 6 | Experimental Hematology & Oncology

Fig. 6

From: Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia

Fig. 6

The influence of Treg on the neutrophil phenotype. a Scheme of the experiment. RAG2KO mice were inoculated with TCL1 leukemic cells alone (TCL1 CD19+) or together with GFP + Treg (TCL1 CD19+ + Treg) sorted from the spleens of TCL1 leukemia-bearing DEREG mice. Upon 28 days, the animals were sacrificed, and splenocytes were isolated to analyze the phenotype of granulocytes by using flow cytometry. b The expression of the selected markers of granulocytes (CD11b+ Ly6G+) isolated from the spleens of RAG2KO mice with no leukemia (CTR) and upon adoptive transfer of TCL1 leukemia cells alone (TCL1 CD19+) or together with GFP+ Treg (TCL1 CD19+ + Treg), MFI – mean fluorescence intensity; each point represents an individual mouse, n = 4–5, Mann‒Whitney U test, ns – not significant, *p ≤ 0.05, **p ≤ 0.01

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Experimental Hematology & Oncology

ISSN: 2162-3619

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