Fig. 1
From: Identification of a novel NPM1 mutation in acute myeloid leukemia
A Alignment of genomic sequences of the new NPM1 exon 5 mutant (highlighted) and exon 12 mutants including canonical type A mutant and other rare mutants that identified in our AML patient cohort. The patient numbers and percentages of different mutants were also indicated. B Graphical representation and predicted protein sequences of NPM1 wildtype, type A mutant and the new NPM1 exon 5 mutant (NPM1_MutSong). The new generated amino acids are highlighted in red. C Alignment of predicted protein sequences of NPM1 wildtype, reported exon 5 mutants and the new NPM1 exon 5 mutant. For the new exon 5 mutant, the predicted NES motif is underlined and highlighted