Fig. 3
From: Focal adhesion kinase: from biological functions to therapeutic strategies
The role of FAK in the tumor microenvironment. FAK not only maintains cancer malignancy but also influences remodeling of the immune microenvironment. For example, FAK can recruit immune cells, cancer-associated fibroblasts, and endothelial cells and even remodel the extracellular matrix. Preclinical studies support the importance of FAK inhibitors in combination with other immunotherapies, and relevant clinical trials are in progress, demonstrating the importance of FAK in oncology treatment