Fig. 1

Schematic diagram of the structural domain of FAK. FAK comprises three primary components, including a central kinase domain, a FERM domain on the N-terminal side, and a FAT domain on the C-terminal side. The kinase domain, which is crucial for catalytic activity, is flanked by three proline-rich regions that are responsible for protein‒protein interactions. The FAK phosphorylation sites and important binding proteins that regulate FAK activity and downstream signaling are highlighted in the diagram