Fig. 2
From: Recent advances and future perspectives in the therapeutics of prostate cancer
Mechanism of action of Taxanes: a Taxane derivatives bind to β tubulin which leads to microtubule stabilization, this inhibits the proper assembly of microtubules and inhibits G2-M transition and apoptosis. b Taxanes are able to inhibit AR activity by FOXO1 mediated inhibition of AR transcriptional activity. c Taxanes inhibit antiapoptotic proteins (BCL2, and BCL-XL) and promotes activation of proapoptotic proteins (BAX, and BAK) leads to the release of cytochrome c that activates intrinsic apoptotic pathway, which leads to cell death (AR: Androgen Receptor and ARE: Androgen Receptor Element)