Table 3 Univariate and multivariate analysis of prognostic factors for overall survival in CRC patients
From: CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression
Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Â | HR (95% CI) | P value | HR (95% CI) | P value |
UTX expression | ||||
 Low expression | Reference |  | Reference |  |
 High expression | 0.615 (0.377–1.001) | 0.051 | 0.683 (0.414–1.125) | 0.134 |
Age | ||||
  ≤ 60 | Reference |  | NA |  |
  > 60 | 1.233 (0.793–1.918) | 0.353 |  |  |
Sex | ||||
 Male | Reference |  | NA |  |
 Female | 1.233 (0.793–1.918) | 0.308 |  |  |
Tumor location | ||||
 Colon | Reference |  | NA |  |
 Return | 0.699 (0.450–1.086) | 0.110 |  |  |
Preoperative serum CEA | ||||
 Normal | Reference |  | Reference |  |
 Elevated | 2.364 (1.501–3.722) |  < 0.001 | 1.689 (1.060–2.694) | 0.028 |
pT stage | ||||
 T2 | Reference |  |  |  |
 T3 | 4.245 (0.930–19.377) | 0.062 | 3.915 (0.840–18.251) | 0.082 |
 T4 | 10.531 (2.579–42.994) | 0.001 | 6.871 (1.649–28.622) | 0.008 |
pN stage | ||||
 0 | Reference |  | Reference |  |
 1 | 2.858 (1.580–5.172) | 0.001 | 0.586 (0.280–1.227) | 0.156 |
 2 | 4.143 (2.334–7.353) |  < 0.001 | 0.708 (0.346–1.451) | 0.346 |
TNM stage | ||||
 I + II | Reference |  | Reference |  |
 III + IV | 6.493 (3.240–13.011) |  < 0.001 | 8.739 (3.227–23.667 |  < 0.001 |
Histologic type | ||||
 Adenocarcinoma | Reference |  | NA |  |
 Mucinous adenocarcinoma | 0.857 (0.314–2.344) |  | 0.764 |  |
Grade | ||||
 Well-Moderately differentiated | Reference |  | NA |  |
 Moderately-Poor differentiated | 1.749 (0.548–5.583) |  | 0.345 |  |
Vessel invasion | ||||
 No | Reference |  | NA |  |
 Yes | 0.990 (0.136–7.201) | 0.992 |  |  |
Nerve invasion | ||||
 No | Reference |  | Reference |  |
 Yes | 1.573 (0.931–2.659) | 0.091 | 0.938 (0.543–1.620) | 0.818 |