Table 2 Univariate and multivariate analysis of prognostic factors for disease-free survival in CRC patients
From: CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression
Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Â | HR (95% CI) | P value | HR (95% CI) | P value |
UTX expression | ||||
 Low expression | Reference |  | Reference |  |
 High expression | 0.595 (0.383–0.925) | 0.021 | 0.619 (0.394–0.972) | 0.037 |
Age | ||||
  ≤ 60 | Reference |  | NA |  |
  > 60 | 1.140 (0.763–1.703) |  | 0.522 |  |
Sex | ||||
 Male | Reference |  | NA |  |
 Female | 0.762 (0.503–1.155) |  | 0.200 |  |
Tumor Location | ||||
 Colon | Reference |  | NA |  |
 Return | 0.809 (0.544–1.202) |  | 0.293 |  |
Preoperative Serum CEA | ||||
 Normal | Reference |  | Reference |  |
 Elevated | 2.606 (1.731–3.922) |  < 0.001 | 1.985 (1.302–3.024) | 0.001 |
pT stage | ||||
 T2 | Reference |  | Reference |  |
 T3 | 2.621 (0.845–8.127) | 0.095 | 2.542 (0.805–8.029) | 0.112 |
 T4 | 6.546 (2.398–17.872) |  < 0.001 | 4.074 (1.466–11.321) | 0.007 |
pN stage | ||||
 0 | Reference |  | Reference |  |
 1 | 3.157 (1.836–5.427) |  < 0.001 | 0.777 (0.378–1.599) | 0.494 |
 2 | 4.434 (2.621–7.501) |  < 0.001 | 0.932 (0.463–1.875) | 0.843 |
TNM stage | ||||
 I + II | Reference |  | Reference |  |
 III + IV | 6.041 (3.298–11.067) |  < 0.001 | 6.111 (2.469–15.122) |  < 0.001 |
Histologic type | ||||
 Adenocarcinoma | Reference |  | NA |  |
 Mucinous adenocarcinoma | 0.870 (0.354–2.141) | 0.762 |  |  |
Grade | ||||
 Well-Moderately differentiated | Reference |  | NA |  |
 Moderately-Poor differentiated | 1.268 (0.512–3.141) | 0.608 |  |  |
Vessel invasion | ||||
 No | Reference |  | NA |  |
 Yes | 1.240 (0.171–8.976) | 0.831 |  |  |
Nerve invasion | ||||
 No | Reference |  | Reference |  |
 Yes | 1.767 (1.107–2.821) | 0.017 | 1.123 (0.689–1.830) | 0.642 |