Table 1 Comparative analysis results for L-MIND compared with other systemic therapies

ORR n (%)

51 (67.1)

37 (48.7)

50 (66.7)

41 (54.7)

51 (68.9)

34 (45.9)

HR (95% CI)

18.42 (1.905–34.204)

12.00 (4.657–28.173)

22.91 (6.285–38.722)

P value

0.0323

0.1810

0.0076

CR n (%)

29 (38.2)

16 (21.1)

29 (38.7)

21 (28.0)

29 (39.2)

17 (23.0)

HR (95% CI)

17.11 (0.579–32.952)

10.67 (-5.987–26.891)

16.22 (-0.548–32.318)

P value

0.0324

0.2252

0.050

Median TTNT (mo)

12.5

6.3

12.1

6.9

12.5

5.7

HR (95% CI)

0.461 (0.314–0.676)

0.527 (0.357–0.780)

0.423 (0.289–0.619)

P value

< 0.0001

0.0011

< 0.0001

Median OS (mo)

34.1

11.6

31.6

9.9

31.6

11.0

HR (95% CI)

0.553 (0.358–0.855)

0.418 (0.272–0.644)

0.467 (0.305–0.714)

P value

0.0068

< 0.0001

0.0003

Median PFS (mo)

12.1

5.5

12.1

7.9

14.1

5.1

HR (95% CI)

0.424 (0.278–0.647)

0.527 (0.344–0.809)

0.433 (0.288–0.653)

P value

< 0.0001

0.0028

< 0.0001

Median DOR (mo)

26.1

6.6

26.1