Fig. 1
Monoclonal antibodies applied in R/R DLBCLs. Many monoclonal antibodies can be used in R/R DLBCLs. Among these, Tafasitamab showed an apparent synergistic effect with Lenalidomide (a). Tafasitamab shows direct cytotoxicity, ADCC and ADCP. Lenalidomide shows direct cytotoxicity, enhances ADCC and stimulates interferon-Ï’ secretion, lowering the NK cell activation threshold and increasing NK cell proliferation by promoting interleukin-2 production (b). Obinutuzumab is a type II anti-CD20 monoclonal antibody with no CD20 internalization and a stronger antitumor effect than Rituximab (type I anti-CD20 monoclonal antibody) (c). ADCC antibody-dependent cell mediated cytotoxicity, ADCP antibody-dependent cell-mediated phagocytosis, CDC complement dependent cytotoxicity