Chimeric antigen receptor engineered natural killer cells for cancer therapy

Zhang, Yalan; Zhou, Weilin; Yang, Jiangping; Yang, Jinrong; Wang, Wei

doi:10.1186/s40164-023-00431-0

Experimental Hematology & Oncology

Table 1 Overview of preclinical studies based on CAR-NK cell therapy for hematological malignancies

From: Chimeric antigen receptor engineered natural killer cells for cancer therapy

Disease	Target	NK cell source	Intracellular domain	Transduction methods	References
B-cell malignancies	CD19	PB-NK	CD28.CD3ζ	Retrovirus	[141]
B-cell malignancies	CD19	PB-NK	4-1BB.CD3ζ	Retrovirus	[142]
B-cell malignancies	CD19	CB-NK	CD28.CD3ζ+IL-15	Retrovirus	[128, 143]
B-cell malignancies	CD19; CD20	NK-92	CD3ζ	Retrovirus	[144]
B-cell malignancies; acute myeloid leukemia	CD19; CD276	NK-92	CD28.CD3ζ	Retrovirus	[145]
B-cell lymphoma; multiple myeloma	CD19; BCMA	NK-92	4-1BB.CD3ζ	Electroporation	[76]
B-cell acute lymphoblastic leukemia	FLT3	NK-92	CD28.CD3ζ	Lentivirus	[146]
B-cell malignancies	CD20	NK-92	CD3ζ	Retrovirus	[147]
B-cell non-Hodgkin lymphoma	CD20	PB-NK	4-1BB.CD3ζ	Electroporation	[148, 149]
T-cell malignancies	CD3	NK-92	4-1BB.CD28.CD3ζ	Lentivirus	[150]
B-cell malignancies T-cell malignancies	CD4	NK-92	CD28.4-1BB.CD3ζ	Lentivirus	[151]
T-cell malignancies	CD3; CD5	NK-92	2B4.CD3ζ/CD28.CD3ζ	Retrovirus	[152]
T-cell malignancies	CD5	NK-92	4-1BB.CD28.CD3ζ	Lentivirus	[153]
T-cell malignancies	CD5	NK-92	CD28.CD3ζ	Lentivirus	[154]
T-cell malignancies	CD5	NK-92	4-1BB.CD3ζ/2B4.CD3ζ	Lentivirus	[155]
T-cell leukemia	CD7	NK-92MI	CD28.4-1BB.CD3ζ	Electroporation	[156]
EBVA3C⁺T-cell lymphoblastic cells	EBNA3C	NK-92MI	4-1BB.CD3ζ	Retrovirus	[157]
Multiple myeloma	CD138	NK-92MI	CD3ζ	Lentivirus	[158]
Multiple myeloma	CD138; CD19	NK-92	CD28.4-1BB.CD3ζ	Lentivirus	[159]
Multiple myeloma	CS1	NK-92	CD28.CD3ζ	Lentivirus	[160]
Multiple myeloma	NKG2D	PB-NK	4-1BB.CD3ζ	Lentivirus	[161]
Acute myeloid leukemia	NKG2D	PB-NK	CD28.4-1BB.CD3ζ+IL-15	Electroporation	[162]
Acute myeloid leukemia	CD33	PB-NK	4-1BB.CD3ζ	Lentivirus	[163]
Acute myeloid leukemia	CD38	KHYG-1; PB-NK	CD28.CD3ζ	Electroporation	[164]
Acute myeloid leukemia	CD123	PB-NK	CD28.4-1BB.CD3ζ	Retrovirus	[165]
Acute myeloid leukemia	CD123	PB-NK	4-1BB.CD3ζ	Retrovirus	[166]
Acute myeloid leukemia	CD123	NK-92	4-1BB.CD28.CD3ζ	Retrovirus	[167]
Acute myeloid leukemia	NPM1c	PB-NK	4-1BB.CD3ζ	Lentivirus	[168]

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ISSN: 2162-3619

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