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Fig. 2 | Experimental Hematology & Oncology

Fig. 2

From: Elevated expression of the RNA-binding protein IGF2BP1 enhances the mRNA stability of INHBA to promote the invasion and migration of esophageal squamous cancer cells

Fig. 2

IGF2BP1 promotes the invasion and migration of ESCC cells in vitro as well as lung metastasis in vivo. (A) Cell viability was quantified using a CCK-8 assay. (B) Cell invasion and migration abilities were examined using Transwell assays. Representative results (left) and statistical plots (right) are shown. (C) Cell motility was assessed by the wound-healing assay. Representative results (left) and statistical plots (right) are shown. (D) Cell metastatic potential was evaluated using an in vivo pulmonary metastasis assay. Representative images of fixed lung tissues (top) and the results of H&E staining (bottom) are shown. The arrows indicate the lung metastatic nodules. The number of metastatic nodules was plotted (right). **P < 0.01; ***P < 0.001; ****P < 0.0001. NC: Negative Control

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Experimental Hematology & Oncology

ISSN: 2162-3619

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