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Fig. 1 | Experimental Hematology & Oncology

Fig. 1

From: Elevated expression of the RNA-binding protein IGF2BP1 enhances the mRNA stability of INHBA to promote the invasion and migration of esophageal squamous cancer cells

Fig. 1

IGF2BP1 is overexpressed in SCC tissues. (A) Representative IHC staining of IGF2BP1 in ESCC and adjacent nonmalignant tissues. Scale bar = 200 μm (100×); scale bar = 50 μm (400×). (B) IGF2BP1 mRNA levels in ESCC patients and normal tissues in TCGA database. **P < 0.01. (C) IGF2BP1 mRNA levels in HNSCC, LUSC, CESC patients and normal tissues in TCGA database. (D) The expression of IGF2BP1 mRNA in all major tissues and organs in the human body was analyzed in the HPA database. (E) IGF2BP1 protein and mRNA levels of ESCC cell lines were analyzed using RT-PCR and Western blotting, respectively. (F) The methylation level of the first intron of the IGF2BP1 gene in the ESCC cell genome was assessed by MSP-PCR. Three pairs of methylated (M) and unmethylated (U) primers targeting three CG sites in the first intron were designed to amplify DNA converted by bisulfite

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Experimental Hematology & Oncology

ISSN: 2162-3619

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