Table 1 The binding kinetics of DuAb or EDuAb to CD3 and CD19 protein
Method | Ligand | Analyte | Ka(1/Ms) | Kd(1/Ms) | KD(M) | Rmax(RU) | Fit Model |
|---|---|---|---|---|---|---|---|
CM5 | Human CD3E&CD3D hHeterodimer Protein | DuAb | 3.14E + 05 | 2.63E-03 | 4.39E-08 | 402.1 | 1:1 binding |
CM5 | Human CD3E&CD3D hHeterodimer Protein | EDuAb | 1.89E + 05 | 7.06E-04 | 3.82E-08 | 639.4 | 1:1 binding |
CM5 | Human CD19 Protein | DuAb | 1.44E + 05 | 5.48E-02 | 3.80E-07 | 206.7 | 1:1 binding |
CM5 | Human CD19 Protein | EDuAb | 2.55E + 05 | 1.65E-02 | 6.45E-08 | 85.3 | 1:1 binding |