Table 2 Influences of SUMOylation in inflammatory TME

NF-κBNF-κB/Snail

SUMO1

Inhibit NF-κBNF-κB/Snail and EMT in HCC through SUMOylating MANF and p65

[54]

MAPK/NF-κBNF-κB

TRIM60

Inhibit MAPK/NF-κBNF-κB and innate immune response via TAK1 SUMOylation

[146]

IκB/NF-κBNF-κB

SUMO1, UBC9

Inhibit NF-κBNF-κB activation via suppressing ubiquitination-induced IκB degradation or with the enhancement of RSUME

[147, 154]

CREB/IκB

SUMO1

Inhibit inflammatory processes via stabilizing CREB and IκB

[148]

IκB/NF-κBNF-κB

SUMO2/3, UBC9

Promote NF-κBNF-κB activity through facilitating IκB degradation

[149]

ReIA/NF-κBNF-κB

PIAS3

Induce NF-κB suppression through ReIA SUMOylation

[150]

IFNβ/IFNAR1, TLRs

SUMO1, SENP6

Restrain NF-κB and TLRs-associated cytokines production.

[151–153]

IL6

UBC9

Alleviate inflammatory infiltration via hub gene IL6

[155]

ROR-γt/IL17A

SUMO1, UBC9

Inhibit inflammation amplification and related cells recruitment via silencing IL-17 A transcription

[144, 145]

RelA, cFos, and cJun

UBC9

Inhibit inflammatory cytokines production through modifying Akt1

[156]

NEMO

SENP1

Inhibit TNF-α and IL-6 expression and NF-κB activation through eliminate NEMO SUMOylation

[103, 157]

NEMO

SENP2

Inhibit DNA damage induced NF-κB activation via NEMO deSUMOylation and form a negative feedback loop in response to genotoxic stimuli

[158

NEMO

SENP6

Inhibit NF-κB activation via Ikk deSUMOylation and CYLD mediated-degradation

[153]

CD45/STAT3/MDSC

SENP1

Inhibit MDSC expansion in several organs via CD45 deSUMOylation and STAT3 phosphorylation

[159]