Fig. 4
From: The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications
Functional sites of SUMOylation inhibitors. Ginkgolic acid, anacardic acid, and kerriamycin B blocks SAE1/2, while Davidiin and tannic acid impairs formation of the SAE1/2-SUMO intermediate. ML-792, TAK981, COH-000, and ML-93 inhibits SUMO E1 as well. Spectomycin B and GSK145, 2-D08, and SUBINS bind to UBC9, disturbing its interaction with SUMO. Triptolide, Momordin Ic and streptonigrin respectively inhibit SENP1 and disrupt SENP1-SUMO1 interaction. GN6958 and Ebselen suppress SENP1 and SENP2 respectively. There is no E3 inhibitor under research. Green inhibitors are natural compound while blue ones are synthetic product