Fig. 2
From: The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications
Crosstalk between SUMOylation related enzymes and hypoxia signaling pathway. SUMOylation related enzymes regulate HIF-1a stability and transcriptional activity through directly mediating its SUMOylation and indirectly influencing other participants involved in hypoxia signaling pathway, causing expression level alteration of critical genes that modulating cancer cells biological processes such as metastasis, angiogenesis, and glycolysis. Meanwhile, hypoxia can also affect expression of some actors via monitoring their SUMOylation state