Fig. 1

Overview of the mutational landscape of the plasma and CSF liquid biopsies from patients. A. Mutation profiles of the most frequently detected genes in the plasma samples, including SNV (single nucleotide variants), CNV (copy number variants), and other alterations. Each column represents a patient, each row represents a gene, and the corresponding mutation rates are provided on the right side. Altered gene information and clinical characteristics are annotated in the right panel. The upper panel showed the number of altered genes. B Mutation profiles of the high mutated genes in the CSF samples C. Discordance of detected altered genes in paired CSF and plasma. cn, copy number; amp, amplification. Negative, genes not be detected in one sample but could be detected in the other kind of sample, or not detected in both samples. Not available, genes not be detected in one sample but detected in the other kind sample; D. Gene counts of shared, CSF-specific, or plasma-specific alteration in paired CASF-plasma samples. CSF, cerebrospinal fluid; BPM, brain parenchymal metastases. BM, brain parenchymal metastases and leptomeningeal metastases