Fig. 2

The association of TP53 co-mutation with clinical outcomes. a best response of patients stratified by TP53 co-mutation status. b, c Kaplan–Meier estimates of PFS b and OS c of patients stratified by TP53 co-mutation status. d Mutation landscape in patients stratified by TP53 co-mutation status. e, f Comparing mutation load of total gene e and HER2 gene f in patients stratified by TP53 co-mutation status. PR partial response, SD stable disease, PD progressive disease, NA not available, MUT mutant, WT wild type, PFS progression free survival, OS overall survival, HR hazard ratio, SNV single nucleotide variant, Freq frequency