Fig. 3

Signaling pathways associated with EZH2 in HCC immunity. Among them, EZH2 inhibits CD4⁺ T cell proliferation by inhibiting miR-22 to activate the Galectin-9/TIM-3 pathway. EZH2 also down-regulates expression of the NKG2D ligand to resist NK-cell-mediated cytotoxicity. EZH2 promotes IL-6 expression with the involvement of CCRK and NF-κB. IL-6 functions in two different ways: promoting the expansion of MDSC; activating JAK1 to increase the glycosylation levels of PD-L1, thereby up-regulating its stability