Fig. 2

Overview of chronic neutropenia etiologies and clinical features in adults. A Bar graph showing the different etiologies of neutropenia, including overlap (upper panel). The lower panel is showing the percentages of CH, Hypo-IgG and MGUS among AIN and LGL cases. The bar graph below the idiopathic (pink) subgroup presents the percentage with high LGL count detected in this cohort. B Oncoplot of all the patients included in our study illustrating cases with AIN (blue), LGL (pink) and features suggestive of cytotoxic T-cell lymphocytes (CTL) including: Vbeta (Vβ) flow cytometry, T-cell receptor (TCR) polymerase chain reaction (PCR), absolute LGL count, bone marrow (BM) LGL infiltrate, and STAT3 mutation (MT). C Bar histogram showing the percentage of patients with an absolute neutrophil count less than 200/μl (red) and less than 500/μl (blue) across each diagnostic subgroup. Pie charts showing percentage of patients with anti-neutrophil autoantibodies (NA) and splenomegaly among all patients with neutropenia (n = 238). D Histograms showing the number (upper panel) and the percentage (lower panel) of patients with gene mutations among different chronic neutropenia causes. The pie chart shows the percentages of different neutropenia causes among patients with gene mutations. E The table outlines all possible pathophysiological mechanisms of neutropenia including overlap causes. LGL: large granular leukemia, CH clonal hematopoiesis, MGUS monoclonal gammopathy of undetermined significance. Hypo-IgG hypogammaglobulinemia, ANC absolute neutrophils count, AI autoimmune, ANA anti-neutrophil antibody, TCUS T-cell clonality of undetermined significance, BCUS B-cell clonality of undetermined significance, CHIP clonal hematopoiesis of indeterminate potential