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Fig. 3 | Experimental Hematology & Oncology

Fig. 3

From: Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing

Fig. 3

A significant increase in exhausted T cells at relapse after BCMA CAR-T cell therapy in R/R-MM. A The tSNE plots of T cells at baseline and progression. B The heatmap of differentially expressed genes in each cluster. C The proportions of T cells of all the clusters at baseline and progression. D The UMAP plots of CD8+TemRA, exhausted CD8+T cells, memory T cells, Naive T cells, Tregs, CD4+TemRA, and Tc17 at baseline and progression. E The heatmap of differentially expressed genes of CD8+TemRA, exhausted CD8+T cells, memory T cells, Naive T cells, Tregs, CD4+TemRA, and Tc17. F The proportion of CD8+TemRA, exhausted CD8+T cells, memory T cells, Naive T cells, Tregs, CD4+TemRA, and Tc17 at baseline and progression

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Experimental Hematology & Oncology

ISSN: 2162-3619

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