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Fig. 1 | Experimental Hematology & Oncology

Fig. 1

From: Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing

Fig. 1

Single-cell sequencing reveals heterogeneous changes in the BM microenvironment of CD45+ cells in R/R-MM patients before and relapse after BCMA CAR-T cell therapy. A Single cell sequencing and analysis fluency chart. B The UMAP projection of CD45+ BM cells of the patients at baseline and progression, including T cells, B/plasm cells, NK cells, monocytes/macrophages, DCs, neutrophils, and HSCs. C The UMAP plots of the patients at baseline and progression. D Dot plot of differentially expressed genes in each cluster. E The UMAP plot of CD14, CD68, and LYZ expression of monocytes/macrophages. F The UMAP plot of FCGR3B and CXCR2 expression of neutrophils. G The UMAP plot of IGHM and CD79A expression of B/plasma cells. H The UMAP plot of CD3D and CD3E expression of T cells. I The UMAP plot of NKG7 and GZLY expression of NK cells. J The UMAP plot of CD1C and MRC1 expression of DC cells. K All the cell type proportions of R/R-MM patients at baseline and progression

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Experimental Hematology & Oncology

ISSN: 2162-3619

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