Fig. 11

Targeted protein expression of the four mice groups. A Representative IHC images of p53, CDC20, cleaved PARP and K-i67 staining of tumor tissues in the control group, the nutlin-3a group, the apcin group, and the nutlin-3a plus apcin group (× 200 magnification; scale bar, 100 μm). B The protein expression of p53, CDC20, cleaved PARP and Ki-67 of tumor tissues were determined by IHC quantitative analysis in the control group, the nutlin-3a group, the apcin group, and the nutlin-3a plus apcin group, which were calculated by the MOD value. *P < 0.05, **P < 0.01, ***P < 0.001