Fig. 10

Injection of nutlin-3a/apcin alone or in combination was safe and tolerable in vivo. A The changes of mice body weight in the control group, the nutlin-3a group, the apcin group, and the nutlin-3a plus apcin group after treatment. ns meant P > 0.05. B Representative HE images of mice heart, liver, and kidney tissues in the four groups (× 200 magnification; scale bar, 100 μm). C Comparison of relevant indexes of the blood biochemistry test among the four groups. ns meant P > 0.05 compared with the control group. D Comparison of relevant indexes of the blood routine test among the four groups. ns meant P > 0.05 compared with the control group