Table 2 Univariate and multivariate analyses of prognostic factors with OS and DFS in HCC (n = 144)

Univariate analysis

 Age, year (≤ 50 vs. > 50)

0.735 (0.472–1.145)

0.174

0.771 (0.502–1.185)

 Sex (Female vs. Male)

1.431(0.688–2.974)

0.338

1.368(0.684–2.736)

 HBsAg (Negative vs. Positive)

1.299 (0.649–2.602)

0.460

1.090 (0.577–2.058)

 AFP, ng/mL (≤ 13.4 vs. > 13.4)

1.556 (0.971–2.495)

0.066

1.645 (1.038–2.608)

 Liver cirrhosis (No vs. Yes)

1.651 (0.824–3.310)

0.157

1.563 (0.806–3.031)

 Tumor size, cm (≤ 5 vs. > 5)

1.566 (1.005–2.441)

0.047

2.094 (1.355–3.235)

 Tumor number (Single vs. Multiple)

1.938 (1.209–3.106)

0.006

2.012 (1.263–3.207)

 Vascular invasion (Negative vs. Positive)

2.147 (1.370–3.364)

0.001

1.908 (1.236–2.945)

 Tumor encapsulation (Complete vs. None)

1.785 (1.132–2.815)

0.013

1.817 (1.172–2.819)

 Tumor differentiation (I + II vs. III + IV)

1.757 (1.124–2.748)

0.013

1.786 (1.155–2.761)

 TNM stage (I vs. II + III)

4.082 (2.420–6.886)

0.000

3.214 (1.982–5.212)

 CDCA8 (Low vs. High)

2.104 (1.334–3.32)

0.001

1.927 (1.241–2.991)

Multivariate analysis

 AFP, ng/mL (≤ 13.4 vs. > 13.4)

NA

NA

1.230 (0.754–2.007)

 Tumor size, cm (≤ 5 vs. > 5)

1.506 (0.941–2.41)

0.088

2.192 (1.382–3.476)

 Tumor number (Single vs. Multiple)

1.649 (1.011–2.691)

0.045

1.663 (1.01–2.738)

 Vascular invasion (Negative vs. Positive)

1.675 (1.017–2.756)

0.043

1.383 (0.853–2.241)

 Tumor encapsulation (Complete vs. None)

1.300 (0.782–2.161)

0.311

1.266 (0.773–2.073)

 Tumor differentiation (I + II vs. III + IV)

1.755 (1.115–2.762)

0.015

1.797 (1.152–2.802)

 CDCA8 (Low vs. High)

1.903 (1.174–3.083)

0.009

1.778 (1.113–2.839)