CDCA8 induced by NF-YA promotes hepatocellular carcinoma progression by regulating the MEK/ERK pathway

Table 1 Correlation between CDCA8 expression and clinical characteristics in HCC (n = 144)

Clinical characteristics	CDCA8 expression		p value
Clinical characteristics	Low (N = 72)	High (N = 72)	p value
Age, year (≤ 50 vs. > 50)
≤ 50	31	37	0.317
> 50	41	35	0.317
Sex (Female vs. Male)
Female	10	9	0.806
Male	62	63	0.806
HBsAg (Negative vs. Positive)
Negative	10	11	0.813
Positive	62	61	0.813
AFP, ng/mL (≤ 13.4 vs. > 13.4)
≤ 13.4	35	18	0.003
> 13.4	37	54	0.003
Liver cirrhosis (Negative vs. Positive)
Negative	11	11	1.000
Positive	61	61	1.000
Tumor size, cm (≤ 5 vs. > 5)
≤ 5 cm	40	36	0.504
> 5 cm	32	36	0.504
Tumor number (Single vs. Multiple)
Single	61	47	0.007
Multiple	11	25	0.007
Vascular invasion (Negative vs. Positive)
Negative	45	33	0.045
Positive	27	39	0.045
Tumor encapsulation (Complete vs. None)
Complete	51	47	0.475
None	21	25	0.475
Tumor differentiation (I + II vs. III + IV)
I + II	48	44	0.488
III + IV	24	28	0.488
TNM stage (I vs. II + III)
I–II	43	18	0.813
III	29	54	0.813

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