Fig. 2

Domains of RHO GTPases. RHO GTPases typically contain a G domain, which is a conserved GDP/GTP-binding domain that participates in nucleotide binding and hydrolysis. Switch I/II regions of RHO GTPase are the common binding sites for GEFs, GDIs, GAPs, or effectors, and undergo conformational changes during the nucleotide exchange and hydrolysis cycle. The C-terminal hypervariable region ends with a common sequence, which is known as CAAX, and modification at this sequence is crucial for subcellular localization of RHO GTPases