Fig. 2
From: The immunometabolic landscape of the bone marrow microenvironment in acute myeloid leukemia
a Biological process and pathway enrichment. The top-scoring pathways related to metabolism and focused on OXPHOS, hinting at the metabolic characteristics of LSCs. b Survival analysis of AML metabolic differential genes (P < 0.005). c Immune escape mechanism of the AML bone marrow microenvironment. In the AML bone marrow microenvironment, leukemia cells compete with immune cells for nutrients and oxygen. Leukemia cells enhance their metabolic activity to satisfy energy demand. Myeloid immune cells are the major energy consumers and increase their proportions of anti-inflammatory cells, which have close communication with leukemia cells. Moreover, T cells weaken the cytotoxic effect by decreasing their metabolic gene expression levels and have little interaction with tumor cells. Furthermore, ENO1, GSTP1, MT-ND4L and UQCR11 are potential metabolic targets for AML treatment