Table 1 Summary of the reagents and materials used in this study

Antibodies

 Ms Cd45.1 PE Clone A20

BD Biosciences

Cat#553776

 Ms Cd45.2 FITC Clone 104

BD Biosciences

Cat#553772

 Ms Cd11b PE CloneM1/70

BD Biosciences

Cat#557397

 Ms Ly-6G/Ly-6C (Sca1) PE Clone RB6-8C5

BD Biosciences

Cat#553128

 Ms CD45R/B220 APC Clone RA3-6B2

BD Biosciences

Cat#553092

 Ms CD3 APC-Cy7 Clone 17A2

BD Biosciences

Cat#560590

 Ms CD117 (c-Kit) Clone 2B8

Biolegend

Cat#105811

 Ms CD150 (SLAM) Clone TC15-12F12.2

Biolegend

Cat#115903

 Ms CD48 Clone HM48-1

Biolegend

Cat#103403

 Ms CD34 Clone HM34

Biolegend

Cat#128609

 Ms CD16/32 Clone 93

Biolegend

Cat#101327

 Ms CD127 (IL-7Ra) Clone A019D5

Biolegend

Cat#351311

 Ms CD135 (Flt3) Clone A2F10

Biolegend

Cat#135309

 Rabbit monoclonal to PUMA

Abcam

Cat#ab9643

 Mouse monoclonal to NOXA

Abcam

Cat#ab13654

 Rabbit polyclonal to p53

Abcam

Cat#ab131442

 H2AX rabbit mAb

Cell signaling

Cat#D17A3

 Monoanti Flag M2

Sigma Aldrich

Cat# F1804

 TXN1 polyAb

ThermoFischer

PA587014

 Beta actin Ab

Santa Cruz

Cat#sc4778

 MDM2 mouse Ab

Santa Cruz

Cat#sc965

 TXN2 Ab

Santa Cruz

Cat#sc133201

 P21 Ab

Santa Cruz

Cat#sc6246

 P16 Ab

Santa Cruz

Cat#sc166760

Chemicals, peptides, and recombinant proteins

 Tamoxifen

Sigma Aldrich

Cat#T5648; CAS 10540-29-1

 Recombinant Human Thioredoxin-1

R&D Systems

Cat#1970-TX

 PenStrep

Gibco

Cat#15140-122

 Direct PCR

Viagen Biotech

102-T

 Iscoves DMEM1X

Corning

10016cv

 RPMI 1640 1X

Corning

10040cv

 FBS Gemini

GeminiBio

100106

 Lipofectamin RNA iMAX

Life technology

13778150

 LE Agarose

Millipore Sigma

Cat#E-3120

Critical commercial assays

 MACS Ms lineage- selection kit

Miltenyi Biotech

Cat#130-090-858

 Annexin V Apoptosis Assay

BD Biosciences

Cat#556547

 ROS assay (H2DCFDA)

Invitrogen

Cat#D399

 MitoProbe JC-1 assay

Invitrogen

Cat#M34152

 CellEvent Senescence Green

Invitrogen

Cat#C10841

Experimental models: cell lines

 Mouse: EML, Clone 1

ATCC

ATCC: CRL-11691

Experimental models: organisms/strains

 Mouse: Txn1^tm1.1Ees/J

Jackson Laboratory

JAX: 030221

 Mouse: B6.Cg-Commd10^{Tg(Vav1-icre)A2Kio}/J

Jackson Laboratory

JAX: 008610

 Mouse: B6.129-Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/J

Jackson Laboratory

JAX: 008463

 Mouse: B6.SJL-Ptprc^a Pepc^b/BoyJ

Jackson Laboratory

JAX: 002014

Oligonucleotides

 Genoyping primers for ROSA-TXN mice (see Table 2)

IDT DNA

JAX genotyping protocols (see above)

Software and algorithms

 GraphPad Prism6

https://www.graphpad.com/

 FlowJo™ v10.8.1

https://www.flowjo.com/solutions/flowjo/downloads

 The R Project for Statistical Computing

https://www.r-project.org/

 Quant studio 6 flex

https://www.thermofisher.com/us/en/home/life-science/pcr/real-time-pcr/real-time-pcr-instruments/quantstudio-systems/models/quantstudio-6-7-pro.html