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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor

Fig. 5

p53 signal pathway is significantly up-regulated in thioredoxin knockout Lin− hematopoietic cells. TXN1fl/fl (control) and ROSA-CreER-TXN1fl/fl mice were treated with tamoxifen (75 mg/kg) i.p. daily for 5 days. Mice were sacrificed at day 10. Bone marrow cells were harvested and enriched for hematopoietic stem/progenitor cells using the lineage depletion kit. The hematopoietic stem/progenitor- enriched cells were then subject to Next generation RNA seq (A). B Pathway enrichment analysis. C Western blot analysis on bone marrow cells harvested from tamoxifen-treated TXN1fl/fl (control) and ROSA-CreER-TXN1fl/fl mice

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Experimental Hematology & Oncology

ISSN: 2162-3619

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