Table 1 Multivariable analysis of prognostic factors for overall survival in patients with MDS
Variables | Univariable | P | Multivariable | P |
|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
Age ≥ 60 years | 1.037 (1.027–1.048) | < 0.0001 | 2.042 (1.561–2.671) | < 0.0001 |
Hemoglobin | 0.994 (0.989–1.000) | 0.037 | ||
ANC | 0.996 (0.927–1.071) | 0.920 | ||
Platelets | 0.997 (0.995–0.998) | < 0.0001 | 0.996 (0.995–0.998) | < 0.0001 |
BM blasts | 1.084 (1.061–1.107) | < 0.0001 | 1.060 (1.035–1.086) | < 0.0001 |
IPSS-R karyotype score | 1.581 (1.414–1.768) | < 0.0001 | 1.582 (1.419–1.764) | < 0.0001 |
U2AF1 | 1.145 (0.855–1.533) | 0.365 | ||
ASXL1 | 1.178 (0.872–2.047) | 0.286 | ||
RUNX1 | 1.438 (1.011–0.989) | 0.040 | ||
SF3B1 | 0.618 (0.396–0.965) | 0.031 | ||
TP53 | 2.823 (2.024–3.938) | < 0.0001 | ||
DNMT3A | 1.439 (0.966–2.143) | 0.074 | ||
TET2 | 1.400 (0.919–2.131) | 0.117 | ||
SRSF2 | 1.589 (1.036–2.438) | 0.034 | ||
BCOR | 0.837 (0.457–1.530) | 0.563 | ||
NRAS | 1.628 (0.981–2.699) | 0.059 | ||
SETBP1 | 1.528 (0.922–2.534) | 0.094 | 1.920 (1.131–3.258) | 0.016 |
EZH2 | 1.647 (0.960–2.824) | 0.065 | ||
STAG2 | 1.066 (0.566–2.007) | 0.808 | ||
NPM1 | 1.090 (0.514–2.309) | 0.823 | ||
PTPN11 | 2.031 (1.137–3.626) | 0.014 | 2.031 (1.119–3.685) | 0.020 |
PHF6 | 1.516 (0.806–2.853) | 0.190 | ||
KMT2D | 0.637 (0.263–1.544) | 0.310 | ||
ZRSR2 | 0.882 (0.364–2.138) | 0.779 | ||
DDX41 | 1.387 (0.712–2.700) | 0.329 | ||
IDH2 | 1.867 (0.922–3.780) | 0.075 | ||
KRAS | 1.472 (0.654–3.311) | 0.342 | ||
GATA2 | 0.941 (0.419–2.115) | 0.887 | ||
WT1 | 1.044 (0.389–2.804) | 0.932 | ||
JAK2 | 0.538 (0.172–1.680) | 0.274 | ||
ETV6 | 1.070 (0.342–3.343) | 0.908 | ||
CEBPA | 2.616 (1.163–5.884) | 0.015 | ||
FLT3 ITD/TKD | 0.651 (0.162–2.620) | 0.546 | ||
CBL | 2.156 (0.958–4.853) | 0.055 | ||
MPL | 1.041 (0.334–3.251) | 0.944 | ||
BCORL1 | 0.049 (0.00–19.796) | 0.325 | ||
FAT1 | 0.753 (0.187–3.030) | 0.685 | ||
CUX1 | 0.359 (0.050–2.559) | 0.306 |