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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti-oxidant production and activating Wnt/β-catenin pathway

Fig. 5

G6PD-mediated Dexa resistance in MM is related to cellular redox levels of NADPH and ROS. a Histogram depicting the relative NADP+/NADPH ratio in WT and G6PD-OE MM cells. b, c ROS content was increased by adding H2O2 (1 mM) in ARP1 (b), and H929 (c) G6PD-OE cells. d WB analysis showed that the expression of G6PD was reduced in ARP1 G6PD-OE cells treated with DHEAS or DHEA. e Histogram showing the relative NADP+/NADPH ratio in ARP1 G6PD-OE cells treated with DHEAS or DHEA. f WB analysis showed that the expression of G6PD was reduced whereas H929 G6PD-OE cells were treated with DHEAS or DHEA. g Histogram depicting the relative NADP+/NADPH ratio in H929 G6PD-OE cells treated with DHEAS or DHEA. h–k ROS content was increased following treatment of DHEAS or DHEA in ARP1 (h, i) and H929 (j, k) G6PD-OE cells. *p < 0.05, **p < 0.01 and ***p < 0.001 were considered statistically significant

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Experimental Hematology & Oncology

ISSN: 2162-3619

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