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Fig. 3 | Experimental Hematology & Oncology

Fig. 3

From: G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti-oxidant production and activating Wnt/β-catenin pathway

Fig. 3

Knockdown of G6PD suppresses MM cell viability and improves the survival of MM mice. a WB analysis confirmed that G6PD-KD MM cells expressed significantly lower levels of G6PD. b MTT assays showed that decreased G6PD decreased MM cell viability. c, d The effect of RRX-001 treatment on cell viability in ARP1 (c) and H929 (d) WT and G6PD-OE cells. e RRX-001 treatment improved the survival of MM-prone C57BL/KaLwRij mice (n = 10). The differences between groups were calculated using a Student’s t-test. **p < 0.01 and ***p < 0.001 were considered statistically significant

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Experimental Hematology & Oncology

ISSN: 2162-3619

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