Table2 The roles and mechanisms of TRIM family proteins in mediating chemoresistance

Overexpression of TRIM7

Osteosarcoma

DOX (Doxorubicin hydrochloride) MTX (Methotrexate)

Promotes the Ubiquitination of BRMS1 (breast cancer metastasis suppressor 1)

[102]

Downregulation of TRIM10

Osteosarcoma

Cisplatin

activates the NF-κB signaling pathway

[244]

Overexpression of TRIM58

Breast cancer

DOX

inactivates p53/p21 axis

[161]

Overexpression of TRIM8

CRC and ccRCC

Cisplatin

Inhibits the stability and activity of P53

[272]

Overexpression of TRIM24

Gastric cancer

5-FU

Upregulates cyclin D1 and Akt phosphorylation

[273]

Overexpression of TRIM17 or Downregulation of TRIM28

Melanoma

DOX

Reduces BCL2A1 (B-cell lymphoma 2-related protein A1) protein levels

[274]

Downregulation of TRIM72

Uveal melanoma

Dacarbazine (DTIC)

Inhibits ubiquitination of MGMT (O6-methylguanine DNA methyl transferase)

[275]

Overexpression of TRIM29

LUAD

Cisplatin

NA

[276]

Overexpression of TRIM23

LUAD

Cisplatin

Regulates glucose metabolism via NF-κB/GLUT1/3 axis

[95]

Overexpression of TRIM46

LUAD

Cisplatin

Enhances glycolysis

[97]

Downregulation of TRIM65

NSCLC

Cisplatin

Regulates miR-138-5p

[277]

Overexpression of TRIM59

NSCLC

Cisplatin

Regulates PTEN/AKT

[278]

Downregulation of TRIM72

NSCLC

Cisplatin

NA

[279]

Overexpression of TRIM11

Nasopharyngeal carcinoma

Multidrug

Inhibits apoptosis and modulates the Daple/β-catenin

[46]

Overexpression of TRIM37

Pancreatic Cancer

5-FU

Promoted promotes ubiquitination of PTEN and activates of the AKT-GSK-3β-β-Catenin

[59]

Overexpression of TRIM31

AML

Daunorubicin

Regulates Wnt/β-catenin pathway

[235]

Downregulation of TRIM21

Glioma

Temozolomide

NA

[77]

Overexpression of TRIM31

Glioma

Temozolomide

Activates PI3K/Akt

[280]

Overexpression of TRIM47

CRC

5-FU

Promotes ubiquitination of SMAD4

[215]

Overexpression of TRIM8

CRC

Chemotherapy

NA

[245]