Fig.3

TRIM family are involved in tumor resistance. At the pre-stage of tumorigenesis, a tiny subset of normal cells undergoes genomic changes to transform into malignant tumor cells. Subsequently, beneficial factors including metabolic reprogramming and ROS contribute to the clonal expansion of tumor cells. Although anti-tumor treatments have been administrated, some tumor cells escape death through all kinds of mechanisms including CSCs phenotypes acquisition and the EMT process. TRIM family functions as different roles in tumorigenesis, modulating the EMT process and CSCs maintenance and affecting cancer therapy sensitivity