Fig.2
From: TRIM family contribute to tumorigenesis, cancer development, and drug resistance
TRIM family members are involved in cancer development. TRIM family members are involved in cancer development through mediating the abnormal cellular signaling pathway transduction including JAK/STAT, PI3K/AKT, TGF-β, Wnt/β-catenin, NF-κB, p53 hub, and other signaling pathways such as Notch, MAPK, AMPK, YAP. TRIMs affect upstream factors and downstream effectors through positive regulations and negative regulations which are mainly achieved by exerting their E3 ligase activity and promoting the ubiquitination degradation of target proteins. By interfering these crucial signaling pathways, TRIMs influence proliferation, migration, and invasion characteristics of cancer cells